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MIDCAB or DES for proximal LAD disease- the quest for optimal patient selection.
Int J Cardiol
January 2025
Bristol Heart Institute, Bristol University, Bristol, UK; Narayana Health, India.
Patellar Instability After Total Knee Arthroplasty.
J Knee Surg
January 2025
Lenox Hill Hospital Department of Orthopedic Surgery, Northwell Health, New York, United States.
Patellar instability following total knee arthroplasty (TKA) is a rare, yet serious complication, potentially requiring revision surgery or resulting in chronic dysfunction. When encountered, it is paramount to understand the etiologies, diagnostic approaches, treatment options, and outcomes of the selected treatment. The most common cause of patella instability is improper positioning of components, leading to lateral maltracking of the patella.
View Article and Find Full Text PDFA morphometric study of posterior tibial slope differences by sex and ethnicity in a South African population.
Surg Radiol Anat
January 2025
University of Pretoria, Pretoria, South Africa.
Purpose: Posterior tibial slope (PTS) influences knee kinetics and kinematics. The purpose of this study was to investigate morphology and variation within a sample of the black and white male and female population.
Method: 480 randomly selected lateral knee radiographs were included.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Irvine, Irvine, CA, USA.
Background: Condensed extracellular matrix structures called perineuronal nets (PNNs) preferentially enwrap the soma and stabilize proximal synapses of parvalbumin-expressing inhibitory neurons in the cortex, serving as a protective barrier against neurotoxins. While PNN structural integrity declines in the healthy aging brain, this reduction is exacerbated in Alzheimer's disease (AD). In the 5xFAD mouse model of amyloidosis, the elimination of microglia prevents reductions in PNN, suggesting microglia are responsible for the over-degradation of PNNs observed in AD.
View Article and Find Full Text PDFQuantification of valvular regurgitation by transthoracic 3D high pulse repetition frequency Doppler echocardiography.
Eur Heart J Imaging Methods Pract
July 2024
Department of Circulation and Medical Imaging, Faculty of Medicine and Health Science, Norwegian University of Science and Technology (NTNU), Prinsesse Kristinas gate 3, Trondheim 7030, Norway.
Aims: To improve quantification of valvular regurgitation, a 3D high-pulse repetition frequency Doppler (3D HPRFD) method was developed for regurgitant volume (RVol) estimation from transthoracic echocardiography (TTE). Although successfully applied and in selected clinical cases, a systematic clinical validation of 3D HPRFD has not been published. Hence, our aims were to investigate (i) feasibility of 3D HPRFD and (ii) correlation between 3D HPRFD and RVol estimates obtained by the 2D proximal isovelocity surface area (PISA) method and cardiac magnetic resonance (CMR) in patients with either aortic regurgitation (AR) or mitral regurgitation (MR).
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