Eleven metabolites, six echinosporins (-), four dibenzoyls (-), and an aromatic compound (), were isolated from the fermentation broth of lichen-associated . The structures of the new compounds (-, -) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra. Amycolasporins A-C () demonstrated antibacterial activities against , , and with MIC values of 25 or 100 μg/mL. Amycolasporin C () and the known dibenzoyl () attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells in a dose-dependent manner.
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| http://dx.doi.org/10.1021/acs.jnatprod.0c00547 | DOI Listing |
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