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Sample composition and HIV prevention indicator differences using physical vs. virtual venue recruitment of men who have sex with men in San Francisco.
Am J Epidemiol
November 2024
Center for Public Health Research, San Francisco Department of Public Health, San Francisco, CA, USA.
During the COVID-19 pandemic, the sampling method for the National HIV Behavioral Surveillance (NHBS) in San Francisco changed from physical venue time-location sampling (TLS) to online or virtual venue TLS for men who have sex with men (MSM). We present differences in the samples of MSM recruited using physical venue TLS in 2017 and virtual venue TLS in 2021. We further assess changes in preventive and risk behaviors from 2017 to 2021 after controlling for differences in the sample compositions with multivariable Poisson models using GLM with robust standard errors.
View Article and Find Full Text PDFPsilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic: A Randomized Clinical Trial.
JAMA Netw Open
December 2024
Fred Hutchinson Cancer Center, Seattle, Washington.
Importance: The psychological morbidity experienced by physicians, advanced practice practitioners (APPs), and nurses from working during the COVID-19 pandemic includes burnout, depression, and posttraumatic stress disorder (PTSD).
Objective: To investigate whether psilocybin therapy could improve symptoms of depression, burnout, and PTSD in US clinicians who developed these symptoms from frontline clinical work during the pandemic.
Design, Setting, And Participants: This double-blind randomized clinical trial enrolled participants from February to December 2022.
Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study.
BMC Psychiatry
November 2024
Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, SE5 8AD, UK.
Background: Despite the availability of evidence-based treatments for anorexia nervosa (AN), remission rates are moderate, and mortality is high. Olanzapine is used as adjunct therapy for AN in case of insufficient response to first-line treatments, even though the evidence is limited. Its effect on eating disorder (ED) psychopathology, its efficacy and tolerability, and its acceptability and adherence rate are unclear.
View Article and Find Full Text PDFPresence of cholestasis and its impact on survival in SARS-CoV-2 associated acute respiratory distress syndrome.
Sci Rep
October 2024
Department of Medicine III, Division of Gastroenterology and Hepatology with Intensive Care Unit 13h1, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- A study aimed to evaluate the prevalence and factors related to cholestasis in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) revealed that 53% of the 225 patients developed cholestasis during their ICU stay.
- The analysis identified that higher levels of certain liver enzymes, inflammation markers, and the use of specific treatments like extracorporeal membrane oxygenation and ketamine were linked to the development of cholestasis.
- Cholestasis was found to be a negative prognostic indicator, as its presence and peak alkaline phosphatase levels were associated with poorer survival rates in the ICU and at six months post-treatment.
Intravenous ketamine successfully treats treatment-resistant catatonia in schizophrenia: A case report.
Pharmacotherapy
October 2024
Houston Methodist Hospital, Houston, Texas, USA.
Article Synopsis
- Benzodiazepines and ECT are primary treatments for catatonia, which can arise from psychiatric or medical conditions, but when they're ineffective, ketamine has been explored as an alternative therapy.
- A case study highlighted a 77-year-old woman with treatment-resistant catatonia due to schizophrenia, who showed a rapid recovery after a single ketamine infusion when ECT was unavailable during the pandemic.
- While ketamine may be a promising option for drug-resistant catatonia, it needs to be used carefully because it could potentially worsen psychosis in patients with schizophrenia, indicating the need for more research in this area.
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