Photocatalytic and biodegradation treatments of paracetamol: investigation of the in vivo toxicity.

Medicines and drugs consumption by all populations of the world can be expected to result in the contamination of the environment since 30-90% of residual drugs will be found into wastewaters. In this study, we investigate the degradation of acetaminophen, selected as a xenobiotic model molecule, via two separate procedures, the TiO impregnated on cellulosic paper photocatalysis, and specific bacterial biodegradation process. Results showed that for initial drug content of 400 mg/L and after 5 hours of processing, around 85% of paracetamol was photocatalytically degraded. The use of Pseudomonas putida E1.21 isolate allowed an abatement of around 92% after 32 h of processing. The acetaminophen toxicity conducted in vivo on laboratory mice showed a net decrease of the creatinine release and enzymes activities like ALP, ALT, AST, and LDH decreased significantly (p < 0.05) when mice were treated distinctly by acetaminophen treated with UV/TiO and the Pseudomonas putida E1.21 strain compared with the control experiments. CAT, MDA, and AchE serum level disruption measurement indicated a serious affection of the mice antioxidant system. These results were found to be in correlation with the ones of the histological analysis of the liver and kidney.