The aim of the study was to determine the prevalence of methicillin-resistant (MRSA) obtained from the nasal cavity of participants and investigate the antibiotic resistance profiles of the isolates from Sokoto state, Nigeria. Nasal swabs of both nares were obtained from 378 participants across three study centers within the six-month study period. The isolates recovered were characterized, and their resistance phenotype determined in conjunction with MRSA prevalence. Phenotypic screening of isolates obtained in this study revealed a total of 131 (17.3%) coagulase-positive Staphylococci out of 756 samples. Of this number, there were 81 (61.8%) , 36 (27.5%) , 6 (4.5%) and 8 (6.1%) . This study found a prevalence of 61.8% and 46.9% of and MRSA among the studied hospitals in Sokoto state, thus demonstrating that the nares of the hospital populace are not free from and MRSA colonization.
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