In this study Vis/NIR spectroscopy was applied to evaluate soluble solids content (SSC) of tomato. A total of 168 tomato samples with five different maturity stages, were measured by two developed systems with the wavelength ranges of 500-930 nm and 900-1400 nm, respectively. The raw spectral data were pre-processed by first derivative and standard normal variate (SNV), respectively, and then the effective wavelengths were selected using competitive adaptive reweighted sampling (CARS) and random frog (RF). Partial least squares (PLS) and least square-support vector machines (LS-SVM) were employed to build the prediction models to evaluate SSC in tomatoes. The prediction results revealed that the best performance was obtained using the PLS model with the optimal wavelengths selected by CARS in the range of 900-1400 nm (Rp = 0.820 and RMSEP = 0.207 °Brix). Meanwhile, this best model yielded desirable results with Rp and RMSEP of 0.830 and 0.316 °Brix, respectively, in 60 samples of the independent set. The method proposed from this study can provide an effective and quick way to predict SSC in tomato.
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http://dx.doi.org/10.1016/j.saa.2020.119139 | DOI Listing |
Int J Pharm
December 2024
Biological Sciences Department, College of Science, King Faisal University, Al Ahsa, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt. Electronic address:
Flavonoids, a type of natural polyphenolic molecule, have garnered significant research interest due to their ubiquitous nature and diverse biological activities, including antioxidant, anti-inflammatory, and anticancer effects, making them appealing to various scientific disciplines. In this regard, the use of a flavonoid nanoparticle delivery system is to overcome low bioavailability, bioactivity, poor aqueous solubility, systemic absorption, and intensive metabolism. Therefore, this review summarizes the classification of nanoparticles (liposomes, polymeric, and solid lipid nanoparticles) and the advantages of using nanoparticle-flavonoid formulations to boost flavonoid bioavailability.
View Article and Find Full Text PDFParasit Vectors
December 2024
Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Background: Cystic echinococcosis (CE) is a common neglected parasitic disease. Nanoparticles containing drugs have been widely utilized in various formulations for several purposes, including improving the bioavailability of drugs by increasing the solubility and dissolution rate of the nanoparticles. The purpose of this study was to evaluate the effects of solid lipid nanoparticles containing albendazole and conjugated to albumin (B-SLN + ABZ) as a novel treatment approach for hydatid cysts in vivo.
View Article and Find Full Text PDFFood Chem
December 2024
Tecnológico Nacional de México, Instituto Tecnológico de Tepic; Laboratorio Integral de Investigación en Alimentos, Av. Tecnológico #2595 Col. Frac. Lagos del Country, C.P., Tepic 63175, Nayarit, Mexico. Electronic address:
Kombucha is a fermented beverage with health effects, made mainly from green tea and black tea; however, it can also be made from other leaves such as those of jackfruit and soursop, which are not used even though they have been reported to have positive health effects. Due to the above, in this work "kombucha" beverages based on jackfruit and/or soursop leaves were developed and analyzed to take advantage of these by-products. It was found that fermentation produced significant changes, being the optimal kombucha formulation green tea with soursop leaves (GTKS), obtaining a higher content of antioxidant compounds (mainly catechin, rutin and shikimic acid) and greater ferric reducing antioxidant power (FRAP) (1.
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Janssen Research & Development, LLC, Discovery Pharmaceutics, San Diego, CA, USA.
Rat pharmacokinetic studies are commonly utilized in early discovery to support absorption, distribution, metabolism, and excretion optimization of active pharmaceutical ingredients (APIs). The aim of this work was to compare exposures from fit-for-purpose oral suspension and solution formulations in rats to guidance provided by the refined Developability Classification System (rDCS) with respect to identifying potential limits to oral absorption, formulation strategy selection, and to optimize oral bioavailability (BA). This investigation utilized six diverse APIs covering a large range of biorelevant solubility, metabolic stability, and oral BA in rats.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
Membraneless organelles (MLOs) formed via protein phase separation have garnered significant attention recently due to their relevance to cellular physiology and pathology. However, there is a lack of tools available to study their behavior and control their bioactivity in complex biological systems. This chapter describes a new optogenetic tool based on water-soluble chlorophyll protein (WSCP), a red light-induced singlet oxygen-generating protein, to control synthetic MLOs.
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