Ample evidence suggests that during word recognition and production, simultaneously activated lexical and sublexical representations interact, demonstrating varied patterns of facilitation and inhibition in various tasks and measures. A separate line of research has led to a growing consensus that prediction during sentence processing involves activating multiple possible predictions. However, very little is known about the nature of the interactions between parallel predictions. The current study employed a speeded cloze task to probe competition between simultaneously activated predictions. We focused on the modal response (the most probable completion for a sentence) and its strongest competitor (the second most probable completion). Examining production latencies of the modal response, the results showed an interaction between competitor strength and the semantic relatedness between the competitor and the modal: when the two were related, the stronger the competitor was, the more it facilitated production; however, when the two were unrelated, the stronger the competitor was, the more inhibition it caused. These results contrast with the pattern observed for the influences of near and distant semantic neighbors on word recognition and production. However, we show that when the different nature of the tasks is taken into consideration, these patterns of interaction between parallel predictions can be accounted for by the interactive activation and competition (IAC) model used to account for previous neighborhood effects (Chen & Mirman, 2012).
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http://dx.doi.org/10.1016/j.cognition.2020.104509 | DOI Listing |
Nat Commun
January 2025
Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic University, Shenzhen, 518055, People's Republic of China.
Crystalline pentacene is a model solid-state light-harvesting material because its quantum efficiencies exceed 100% via ultrafast singlet fission. The singlet fission mechanism in pentacene crystals is disputed due to insufficient electronic information in time-resolved experiments and intractable quantum mechanical calculations for simulating realistic crystal dynamics. Here we combine a multiscale multiconfigurational approach and machine learning photodynamics to understand competing singlet fission mechanisms in crystalline pentacene.
View Article and Find Full Text PDFDrug Metab Dispos
January 2025
Department of Pharmacotherapy and Translational Research, College of Pharmacy, Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, Florida. Electronic address:
Many factors cause interperson variability in the activity and expression of the cytochrome P450 (CYP) drug-metabolizing enzymes in the liver, leading to variable drug exposure and treatment outcomes. Several liver-enriched transcription factors are associated with CYP expression, with estrogen receptor α (ESR1) and constitutive androstane receptor (CAR or NR1I3) being the 2 top factors. ESR1 and NR1I3 undergo extensive alternative splicing that results in numerous splice isoforms, but how these splice isoforms associate with CYP expression is unknown.
View Article and Find Full Text PDFWater Res
January 2025
Department of Biotechnology, Delft University of Technology, Delft, The Netherlands; Wetsus, European Centre of Excellence for Sustainable Water Technology, Leeuwarden, The Netherlands; School of Chemical Engineering, University of Queensland, St. Lucia, Australia. Electronic address:
Significant progress has been made over the past decade with pilot scale polyhydroxyalkanoate (PHA) production by direct accumulation using municipal waste activated sludge (WAS). However, industrial upscaling experiences are still lacking in the research literature. In this study, a demonstration scale (4 m) PHA production process was operated using industrially relevant equipment and compared favourably to those from parallel pilot scale (200 L) production runs.
View Article and Find Full Text PDFNat Rev Urol
January 2025
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Approximately 20% of paediatric and adolescent/young adult patients with renal tumours are diagnosed with non-Wilms tumour, a broad heterogeneous group of tumours that includes clear-cell sarcoma of the kidney, congenital mesoblastic nephroma, malignant rhabdoid tumour of the kidney, renal-cell carcinoma, renal medullary carcinoma and other rare histologies. The differential diagnosis of these tumours dates back many decades, when these pathologies were identified initially through clinicopathological observation of entities with outcomes that diverged from Wilms tumour, corroborated with immunohistochemistry and molecular cytogenetics and, subsequently, through next-generation sequencing. These advances enabled near-definitive recognition of different tumours and risk stratification of patients.
View Article and Find Full Text PDFDiabetol Int
January 2025
Department of Plastic and Reconstructive Surgery and Maxillofacial Surgery, Kurume University School of Medicine, Kurume, Japan.
Aim: Patients with diabetes are frequently complicated with diabetic foot ulcers (DFUs) which are vulnerable to recurrence after healing. We retrospectively surveyed the recurrence of foot ulcer and related factors in Japanese patients with DFUs.
Subjects And Methods: Forty-two feet of 39 patients were initially recruited in this study.
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