AI Article Synopsis
- Diabetes mellitus (DM) and heart failure (HF) often occur together, leading to serious health issues and high death rates globally.
- Current treatments for lowering blood sugar in DM are not effectively reducing hospitalization and death rates, and heart failure cases are still on the rise.
- The review examines how existing diabetes medications affect heart failure outcomes and explores new management strategies and underlying mechanisms for better treatment options.
Article Abstract
Diabetes mellitus (DM) and heart failure (HF) are comorbid conditions associated with significant morbidity and mortality worldwide. Despite the availability of novel and effective therapeutic options and intensive glycaemic control strategies, mortality and hospitalisation rates continue to remain high and the incidence of HF persists. In this review, we described the impact of currently available glucose-lowering therapies in DM with a focus on HF clinical outcomes. Non-conventional modes of management and alternative pathophysiological mechanisms with the potential for therapeutic targeting are also discussed.
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| http://dx.doi.org/10.2174/1381612826666201118091659 | DOI Listing |
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