Molecular subtyping of urothelial carcinoma (UC) is similar to that of breast cancer and is based on the developmental biology approach. The aim of the present study is to assess the prognostic impact of CK5, CK14, and CK20 expression in urinary bladder cancer (UBC) with the potential to stratify them into different subtypes. The current study examined the immunohistochemical expression of CK5, CK14, and CK20 in 90 specimens of UBC. CK5 was expressed in 81.1% of the cases and was significantly associated with old age, muscle invasion, presence of bilharziasis, and tendency for poor overall survival. CK20 was expressed in 47.8% of the cases and was associated with nonmuscle invasion and pure UC while 50% of the cases expressed CK14 that were associated with muscle invasion and perineural invasion. Most squamous cell carcinoma and those associated with bilharziasis were belonged to Ck5+/CK20- subgroup while pure UC and those lacked bilharziasis were located in the Ck5+/CK20+ subgroup. The basal group (Ck5+/CK14+/CK20-) showed high proliferative features compared to the intermediate group (Ck5+/CK14-/CK20-). Generally, presence of CK5 is associated with adverse features especially in the group lacking CK20; however, basal and intermediate subgroups share CK5 expression but they show different proliferative capacities, so their distinction by CK14 is helpful.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15321819.2020.1845726 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cell division cycle 6 is an independent prognostic biomarker in breast cancer.
Pathology
November 2024
Nottingham Breast Cancer Research Centre, Academic Unit for Translational Medical Sciences, School of Medicine, University of Nottingham Biodiscovery Institute, University Park, Nottingham, UK; Pathology Department, Nottingham University Hospitals NHS Trust, Nottingham, UK; Pathology Department, Hamad Medical Corporation, Doha, Qatar. Electronic address:
Article Synopsis
- CDC6 is a protein that plays a key role in cell division and cancer cell behavior, and this study examines its impact on breast cancer prognosis using large data sets from various cohorts.
- High levels of CDC6 are linked to aggressive cancer traits, like larger tumors and negative hormone receptor status, suggesting that it might indicate a poorer patient outcome.
- The findings support the idea that CDC6 could be a valuable prognostic factor and a potential target for breast cancer therapies, needing more research to explore its functional role.
Application of mass cytometry in multiparametric characterization of precancerous cervical lesions.
Cytometry B Clin Cytom
October 2024
Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia.
Cervical cancer (CC) is the fourth most common malignant tumor in women worldwide. Detecting different biomarkers together on single cells by novel method mass cytometry could contribute to more precise screening. Liquid-based cytology (LBC) cervical samples were collected (N = 53) from women categorized as normal and precancerous lesions.
View Article and Find Full Text PDF3D Porous Polymer Scaffold-Conjugated KGF-Mimetic Peptide Promotes Functional Skin Regeneration in Chronic Diabetic Wounds.
ACS Appl Mater Interfaces
July 2024
Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Uppal Road, Tarnaka, Hyderabad 500007, Telangana, India.
The re-epithelialization process gets severely dysregulated in chronic nonhealing diabetic foot ulcers/wounds. Keratinocyte growth factor (KGF or FGF-7) is the major modulator of the re-epithelialization process, which regulates the physiological phenotypes of cutaneous keratinocytes. The existing therapeutic strategies of growth factor administration have several limitations.
View Article and Find Full Text PDFAn Unusual Presentation of Synchronous Breast Cancer and Skin Malignancy in a Patient with Lynch Syndrome: A Case Report and Review of the Literature.
Biomedicines
June 2024
Cellular Pathology, Queen Elizabeth Hospital Birmingham, Birmingham B15 2GW, UK.
Background: Lynch syndrome is an autosomal dominant condition that leads to an increased risk of many neoplasms. In the United Kingdom, NICE recommends that patients with colorectal and endometrial cancer should be tested for Lynch syndrome. There is conflicting evidence in the literature on the link between breast cancer and Lynch syndrome.
View Article and Find Full Text PDFThe value of oestrogen receptor, progesterone receptor and keratins 5 and 14 immunohistochemistry in the evaluation of epithelial proliferations at cauterised margins in breast-conserving surgery specimens.
Pathol Res Pract
May 2024
Department of Pathology, University of Szeged, Albert Szent-Györgyi Medical Centre, Állomás u. 1, Szeged 6725, Hungary; Department of Pathology, Bács-Kiskun County Teaching Hospital., Nyíri út 38, Kecskemét 6000, Hungary.
In breast conservative surgery, it is sometimes difficult to decide whether the cauterised tissue at the inked margin represents normal / hyperplastic or neoplastic tissue. We retrospectively assessed the value of ER, PR, CK5 and CK14 IHC in clarifying the nature of cauterised tissues at the margins concerning 34 lesions of 23 patients. 27 cases belonged to lesions that could not be adequately classified on the basis of the HE stains.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!