We study the q-state active Potts model (APM) on a two-dimensional lattice in which self-propelled particles have q internal states corresponding to the q directions of motion. A local alignment rule inspired by the ferromagnetic q-state Potts model and self-propulsion via biased diffusion according to the internal particle states elicits collective motion at high densities and low noise. We formulate a coarse-grained hydrodynamic theory with which we compute the phase diagrams of the APM for q=4 and q=6 and analyze the flocking dynamics in the coexistence region, where the high-density (polar liquid) phase forms a fluctuating stripe of coherently moving particles on the background of the low-density (gas) phase. A reorientation transition of the phase-separated profiles from transversal band motion to longitudinal lane formation is found, which is absent in the Vicsek model and the active Ising model. The origin of this reorientation transition is revealed by a stability analysis: for large velocities the transverse diffusivity approaches zero and stabilizes lanes. Computer simulations corroborate the analytical predictions of the flocking and reorientation transitions and validate the phase diagrams of the APM.
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http://dx.doi.org/10.1103/PhysRevE.102.042601 | DOI Listing |
Front Cell Dev Biol
January 2025
Mathematical Institute, Faculty of Science, Leiden University, Leiden, Netherlands.
Many mammalian cells, including endothelial cells and fibroblasts, align and elongate along the orientation of extracellular matrix (ECM) fibers in a gel when cultured . During cell elongation, clusters of focal adhesions (FAs) form near the poles of the elongating cells. FAs are mechanosensitive clusters of adhesions that grow under mechanical tension exerted by the cells' pulling on the ECM and shrink when the tension is released.
View Article and Find Full Text PDFBMJ Open Respir Res
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Introduction: Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.
Methods: The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments.
Soft Matter
January 2025
Institute for Solid State Physics, University of Tokyo, Kashiwa, Chiba 277-8581, Japan.
Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. We consider that molecules bind to either surface of a bilayer membrane and move to the opposite leaflet by flip-flop. When binding does not modify the membrane properties and the transfer rates among the three states are cyclically symmetric, the membrane exhibits spiral-wave and homogeneous-cycling modes at high and low binding rates, respectively, as in an off-lattice cyclic Potts model.
View Article and Find Full Text PDFNPJ Vaccines
January 2025
Providence Therapeutics Holdings, Inc., Calgary, Canada.
Continuously emerging SARS-CoV-2 Omicron subvariants pose a threat thwarting the effectiveness of approved COVID-19 vaccines. Especially, the protection breadth and degree of these vaccines against antigenically distant Omicron subvariants is unclear. Here, we report the immunogenicity and efficacy of a bivalent mRNA vaccine, PTX-COVID19-M1.
View Article and Find Full Text PDFBiol Sport
January 2025
School of Science and Technology, University of New England, Armidale, Australia.
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