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| http://dx.doi.org/10.1016/S1473-3099(20)30722-2 | DOI Listing |
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Multiplex sample-sparing assay for detecting type-specific antibodies to Zika and dengue viruses: an assay development and validation study.
Lancet Microbe
December 2024
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address:
Background: Serology for dengue viruses (DENV) and Zika virus (ZIKV) has been hindered by antibody cross-reactivity, which limits the utility of these tests for surveillance and assessment of sero-status. Our aim was to develop a multiplexed IgG-based assay with increased accuracy to assess the history of previous DENV and ZIKV infections.
Methods: We developed and assessed the analytical performance of a sample-sparing, multiplexed, microsphere-based serological assay using domain III of the envelope protein (EDIII) of DENV serotypes 1-4 and ZIKV, the most variable region between each virus.
Dengue Cardiomyopathy Treatment Strategy Optimisation by Integrating Point of Care Ultrasound (POCUS) with VExUS.
POCUS J
November 2024
Medical Department, Limbang Hospital Sarawak MYS.
Dengue fever is an arthropod-borne viral disease that is widespread throughout the world. We report a case of dengue cardiomyopathy that was detected and treated to best effect using point of care ultrasound (POCUS) and the VExUS score. A 75-year-old lady with no known comorbidities presented with a ten-day history of fever, vomiting, loose stool, and poor appetite.
View Article and Find Full Text PDFSignatures of transmission in within-host Mycobacterium tuberculosis complex variation: a retrospective genomic epidemiology study.
Lancet Microbe
January 2025
Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Background: Mycobacterium tuberculosis complex (MTBC) species evolve slowly, so isolates from individuals linked in transmission often have identical or nearly identical genomes, making it difficult to reconstruct transmission chains. Finding additional sources of shared MTBC variation could help overcome this problem. Previous studies have reported MTBC diversity within infected individuals; however, whether within-host variation improves transmission inferences remains unclear.
View Article and Find Full Text PDFDiagnostics for optimised dengue surveillance: a qualitative focus group study to investigate user experience and requirements in Thailand.
BMJ Open
November 2024
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Objectives: Effective, real-time surveillance of dengue may provide early warning of outbreaks and support targeted disease-control intervention but requires widespread accurate diagnosis and timely case reporting. Research directing innovation in diagnostics for dengue surveillance is lacking. This study aimed to describe experience and requirements of relevant prospective users.
View Article and Find Full Text PDFPredicting deterioration in dengue using a low cost wearable for continuous clinical monitoring.
NPJ Digit Med
November 2024
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Close vital signs monitoring is crucial for the clinical management of patients with dengue. We investigated performance of a non-invasive wearable utilising photoplethysmography (PPG), to provide real-time risk prediction in hospitalised individuals. We performed a prospective observational clinical study in Vietnam between January 2020 and October 2022: 153 patients were included in analyses, providing 1353 h of PPG data.
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