We herein report the deoxyfluorination of cyclic α-hydroxy-β-ketoesters using diethylaminosulfur trifluoride (DAST). The reaction proceeds with excellent levels of stereospecificity, giving the configurationally inverted α-fluoro-β-ketoesters in high yields under operationally simple conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116657 | PMC |
| http://dx.doi.org/10.1039/d0ob02152k | DOI Listing |
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