Introduction: Various genome wide association studies have manifested that Major Histocompatibility Complex (MHC) region on chromosome 6p21 houses many potential candidate genes for asthma.
Objective: This Case-Control association study was planned to determine the association of 10 Single Nucleotide Polymorphisms (SNPs), residing within and around MHC genes' region on chromosome 6p21, with Asthma in Punjabi population of Lahore, Pakistan.
Methods: A total of 161 subjects, 61 physician-diagnosed asthma patients and 100 age-matched healthy controls, were recruited from Lahore, a city in Punjab. Ten single nucleotide polymorphisms (SNPs) (rs9378249, rs2070600, rs404860, rs6689, rs1049124, rs1063355, rs1049225, rs1049219, rs7773955 and rs928976) located within or near AGER, NOTCH and HLA genes in MHC region, were genotyped in both patients and controls using single base extension reaction and capillary electrophoresis-based genetic analyser. Statistical models were applied using SHEsis Plus. Results were adjusted for various cofactors (age, gender and environment) and by applying multiple corrections. Haplotype and linkage disequilibrium analyses were performed on Haploview software v4.1.
Results: Three of the studied SNPs rs1049124, rs1049219 and rs7773955 show independent significant association with asthma under allelic and genotypic models. Two of the haplotypes, H7 and H13, "CTAATTT" and "CCACTAT", respectively, for rs2070600, rs404860, rs6689, rs1049124, rs1063355, rs1049219 and rs7773955, are found to be significantly associated with the disease.
Conclusion: This study reports association of SNP variants residing on HLA-DQB1 and HLA-DQA2 genes and haplotypes H7 and H13 on genomic region 6p21 with Asthma in the Punjabi population of Lahore, Pakistan.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/crj.13309 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender differences in the context of interventions for improving health literacy in migrants: a qualitative evidence synthesis.
Cochrane Database Syst Rev
December 2024
Cochrane Haematology, Institute of Public Health, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Background: Health literacy can be defined as a person's knowledge, motivation and competence in four steps of health-related information processing - accessing, understanding, appraising and applying health-related information. Individuals with experience of migration may encounter difficulties with or barriers to these steps that may, in turn, lead to poorer health outcomes than those of the general population. Moreover, women and men have different health challenges and needs and may respond differently to interventions aimed at improving health literacy.
View Article and Find Full Text PDFCo-production in practice: A qualitative study of the development of advance care planning workshops for South Asian elders.
Palliat Med
January 2025
Palliative and End of Life Research Group, Bristol Medical School, University of Bristol, Bristol, UK.
Background: Advance care planning can improve patient and family outcomes; however, minoritised ethnic communities experience access barriers. Co-production offers a way to design culturally appropriate information and support, but evidence is needed to understand its implementation in palliative care.
Aim: To explore and describe how two charities used co-production to develop and deliver community-based advance care planning workshops for South Asian elders.
Suggestive evidence of male specific genetic association of IL8 -251T>A promoter polymorphism with primary angle closure glaucoma in a north Indian Punjabi population.
BMC Ophthalmol
December 2024
Department of Human Genetics, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
Article Synopsis
- The study examines how the -251T > A variant in the IL8 gene affects the risk of developing primary angle closure glaucoma (PACG) in a North Indian Punjabi population, focusing on its genetic association.
- A total of 226 POAG, 132 PACG patients, and 424 controls were analyzed; results showed a significant association between the variant and PACG in males, indicating that certain genotypes may offer protective effects.
- The findings highlight a potential genetic factor contributing to sex differences in glaucoma susceptibility, suggesting the need for further research into the biological mechanisms driving this disparity.
Genetic Diversity and Forensic Utility of X-STR Loci in Punjabi and Kashmiri Populations: Insights into Population Structure and Ancestry.
Genes (Basel)
October 2024
Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University, Xiamen 361000, China.
Article Synopsis
- X-chromosomal short tandem repeats (X-STRs) are vital for forensic investigations and understanding population genetics, yet there's scarce data on their variation in Pakistani ethnic groups, specifically Kashmiris and Punjabis.
- This research examined 12 X-STRs from 125 families (75 Kashmiri and 50 Punjabi) in Pakistan, showcasing 222 total alleles, with allele frequencies varying widely, and highlighting specific loci variance in polymorphism.
- Findings indicated strong discrimination power for kinship analysis and revealed distinct genetic structures between Kashmiri and Punjabi populations, emphasizing their unique genetic backgrounds and differences from East Asian groups.
Heart failure after left atrial appendage occlusion: Insights from the LAAOS III randomized trial.
Eur J Heart Fail
November 2024
McMaster University, Hamilton, ON, Canada.
Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III).
Methods And Results: Patients (n = 4811) with atrial fibrillation (AF) and a CHADS-VASc score ≥2, who were having cardiac surgery for another indication, were randomized to undergo surgical LAAO or not.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!