Objective: Asthma has been associated with worse academic performance in a single school year, yet this association may be magnified over time as students with asthma continue to fall behind. This study examined the relationship between asthma and standardized test performance aggregated across 3 school years, including whether performance varied by likelihood of having significant asthma.
Methods: Data were from students in grades K-8 at 2 urban public schools in the Northeastern United States (2015-2018). Asthma was based on parent- and self-report and school health center records. Standardized test performance was assessed using Measures of Academic Progress (MAP) and Partnership for Assessment of Readiness for College and Careers (PARCC). Mixed effects linear and logistic regression models were used to evaluate the relationship between asthma and performance during 3 school years.
Results: Any asthma was associated with worse MAP performance across the 3 academic years. Students with the most significant asthma demonstrated worse performance on MAP and PARCC. Aggregating across 3 school years, students scored 3.17 points worse on MAP reading (95% confidence interval [CI]: 0.7-5.63; P = .012) and 3.56 points worse on MAP mathematics (95% CI: 0.52-6.6; P = .022); they had 48.8% (95% CI: 1.9%-73.2%; P = .044) and 58.0% (95% CI: 21%-78%; P = .007) lower odds of proficiency on PARCC English/Language Arts and Mathematics, respectively compared to those without asthma.
Conclusions: The relationship between asthma and poorer academic achievement in 1 school year may be magnified over multiple years, particularly among those with more significant asthma. School-based asthma interventions may support academic growth and more equitable health outcomes.
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http://dx.doi.org/10.1016/j.acap.2020.11.006 | DOI Listing |
Aging Clin Exp Res
December 2024
Department of Geriatric Neurology, Shaanxi Provincial People's Hospital, No.256, Youyi West Road, Xi'an 710068, China.
Background: The correlation between asthma and frailty is increasingly garnering attention. The association between asthma and frailty remains inconclusive in observational studies, and the causality of this relationship still needs to be established.
Aims: Therefore, we employed two-sample Mendelian randomization analyses using genetic instruments to determine the causal association of asthma on frailty.
Environ Res
December 2024
University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland. Electronic address:
Background: Little is known about the mediating role of nasal microbiome on the association between pre- and postnatal air pollution exposure and subsequent respiratory morbidity in infancy. We aimed to examine the impact of air pollution on microbiome and respiratory symptoms, and whether microbiome mediates the association between air pollution and symptoms.
Methods: Nasal swabs from 270 infants in the prospective Basel-Bern Infant Lung Development cohort were analyzed by 16S ribosomal RNA gene sequencing.
Environ Res
December 2024
Perelman School of Medicine, University of Pennsylvania, 3451 Walnut St, Philadelphia, PA 19104, USA; The Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, 19104, Philadelphia, PA, USA; Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, 19104, Philadelphia, PA, USA.
Rationale: Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap.
Objectives: To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma.
J Allergy Clin Immunol
December 2024
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Background: MicroRNAs (miRNAs) are involved in the biological regulation of asthma and allergies.
Objectives: To investigate the association between cord blood miRNAs and the development of allergic rhinitis and early childhood asthma.
Methods: miRNAs were sequenced from cord blood of subjects participating in the Vitamin D Antenatal Asthma Reduction Trial.
J Allergy Clin Immunol
December 2024
University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA. Electronic address:
Over the past two decades, guidelines for the on-demand treatment of hereditary angioedema (HAE) attacks have undergone significant evolution. Early treatment guidelines, such as the Canadian 2003 International Consensus Algorithm, often gated on-demand treatment by attack location and/or severity. Pivotal trials for on-demand injectable treatments (plasma-derived C1 esterase inhibitor [C1INH], icatibant, ecallantide [US only], recombinant C1INH), which were approved in the US and EU between 2008-2014, were designed accordingly.
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