Time study on the uptake of four different beta-blockers in garden cress (Lepidium sativum) as a model plant.

Environ Sci Pollut Res Int

Institute of Analytical Chemistry, Johannes Kepler University, Altenbergerstrasse 69, 4040, Linz, Austria.

Published: November 2021

The aim of this study was to investigate the uptake of four beta-blockers by the model plant Lepidium sativum (garden cress) and their possible metabolization over a time period of 8 days. Therefore, cress was grown hydroponically in tap water for a week until they were matured, following irrigation with drug-containing water over the course of another 8 days. Samples were taken at days 1, 2, 4, and 8 after irrigation started. All four beta-blockers were taken up by the plants and the different octanol-water coefficients (log P) of the drugs have an influence on the uptake speed in the roots of the plants. The log P seems to have no influence on the translocation of the drugs from the root to the shoots. Furthermore, neither phase I nor phase II metabolization occurred inside the plants.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541974PMC
http://dx.doi.org/10.1007/s11356-020-11610-5DOI Listing

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