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Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response.
Sci Rep
December 2024
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, 27599, USA.
A long-standing goal of neuroimaging is the non-invasive volumetric assessment of whole brain function and structure at high spatial and temporal resolutions. Functional ultrasound (fUS) and ultrasound localization microscopy (ULM) are rapidly emerging techniques that promise to bring advanced brain imaging and therapy to the clinic with the safety and low-cost advantages associated with ultrasound. fUS has been used to study cerebral hemodynamics at high temporal resolutions while ULM has been used to study cerebral microvascular structure at high spatial resolutions.
View Article and Find Full Text PDF3D-printed acoustic metasurface with encapsulated micro-air-bubbles for frequency-selective manipulation.
Lab Chip
December 2024
College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, China.
Acoustic waves provide an effective method for object manipulation in microfluidics, often requiring high-frequency ultrasound in the megahertz range when directly handling microsized objects, which can be costly. Micro-air-bubbles in water offer a solution toward low-cost technologies using low-frequency acoustic waves. Owing to their high compressibility and low elastic modulus, these bubbles can exhibit significant expansion and contraction in response to even kilohertz acoustic waves, leading to resonances with frequencies determined and tuned by air-bubble size.
View Article and Find Full Text PDFTowards affordable biomedical imaging: Recent advances in low-cost, high-resolution optoacoustic microscopy.
J Microsc
December 2024
Department of Biology, University of Crete, Voutes University Campus, Heraklion, Crete, Greece.
This short review discusses the recent developments in low-cost, high-resolution optoacoustic microscopy systems, integrating laser diodes for signal excitation, which are 20-40 times cheaper than the typically employed Q-switched nanosecond laser sources. The development of laser diode-based microscopes can substantially improve not only cost efficiency, but also multispectral capabilities, robustness, portability and overall imaging performance of the optoacoustic technique. To this end, we demonstrate relevant implementations in both time and frequency domain, highlighting their representative applications in biomedical research such as microvasculature imaging, oxygen saturation assessments, hybrid and multiview microscopy of model organisms and tissues and Doppler flow speed measurements.
View Article and Find Full Text PDFUsing photonics to measure the characteristics of an RF signal has a number of advantages compared to electronics. As a result, many photonics-based RF signal measurement systems have been reported. However, none of them can simultaneously measure an RF signal angle-of-arrival (AOA) and Doppler frequency shift (DFS) while having a simple and low-cost structure that is suitable for use in a long baseline antenna array.
View Article and Find Full Text PDFExploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography.
Biomed Opt Express
August 2024
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna 1090, Austria.
Low-cost optical coherence tomography has recently emerged as a growing field due to the increased need for general availability of OCT devices outside of the clinics. One of the main obstacles in creating low-cost SS-OCT systems is the price of the laser. In this work, we study the influence of different tuning parameters (e.
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