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Clinical Manifestations.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Alzheimer's disease (AD) causes increasing cognitive and functional impairments, and both are therefore important outcome measures for intervention studies. Cognition and everyday functioning are often used interchangeably, yet the extent of their relationship is still unclear. We therefore aim to assess the relationship between different cognitive domains and everyday functioning across the AD spectrum.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Noord-Holland, Netherlands.
Background: Sporadic bvFTD is often misdiagnosed as a primary psychiatric disorder (PPD) due to overlapping clinical features and lack of reliable biomarkers. The multi-centre study DIPPA-FTD aims to develop diagnostic- and prognostic-algorithms that can distinguish sporadic bvFTD from late-onset PPD. The aim of the retrospective DIPPA-FTD study was to identify the strongest clinical discriminators.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Background: Language is frequently affected in patients with sporadic amyotrophic lateral sclerosis (sALS), with reduced performance in naming, syntactic comprehension, grammatical expression, and orthographic processing. In a previous study, we demonstrated that the language profile of patients with familial type 8 ALS (ALS8), linked to p.P56S VAPB mutation, is similar to sALS.
View Article and Find Full Text PDFRelationship of serum irisin levels, physical activity, and metabolic syndrome biomarkers in obese individuals with low-calorie intake and non-obese individuals with high-calorie intake.
J Health Popul Nutr
January 2025
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Background: Despite all the advances in our knowledge regarding obesity, our understanding of its etiology is still far from complete. This study aimed to evaluate the association of serum irisin levels with physical activity and some of the metabolic syndrome-related biomarkers among obese people with low-calorie intake and non-obese people with high-calorie intake.
Methods: Obese and non-obese healthy individuals with respectively low and high-calorie intakes were recruited.
Not so binary or generalizable: Brain sex differences with artificial neural networks.
Proc Natl Acad Sci U S A
January 2025
Stanson Toshok Center for Brain Function and Repair, Chicago Medical School, Rosalind Franklin University, North Chicago, IL 60064.
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