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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis. | LitMetric

AI Article Synopsis

Article Abstract

Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as well as kidney and liver fibrosis models. Transcriptome analyses reveal that genes involved in fatty acid oxidation are significantly perturbed. Furthermore, mitochondrial dysfunction and acylcarnitine accumulation are found in fibrotic tissues. Substantial downregulation of the PGC1α gene is evident in both and fibrosis models, suggesting a common node of metabolic signature for tissue fibrosis. In order to identify suppressors of fibrosis, we carry out a compound library phenotypic screen and identify AMPK and PPAR as highly enriched targets. We further show that pharmacological treatment of MK-8722 (AMPK activator) and MK-4074 (ACC inhibitor) reduce fibrosis . Altogether, our work demonstrate that metabolic defect is integral to TGF-β signaling and fibrosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659620PMC
http://dx.doi.org/10.1016/j.xcrm.2020.100056DOI Listing

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