A TAD Skeptic: Is 3D Genome Topology Conserved?

Trends Genet

Department of Human Genetics, University of Chicago, Cummings Life Science Center, 928 E. 58th St., Chicago, IL 60637, USA; Section of Genetic Medicine, Department of Medicine, University of Chicago, 5841 S. Maryland Ave., N417, MC6091, Chicago, IL 60637, USA. Electronic address:

Published: March 2021

The notion that topologically associating domains (TADs) are highly conserved across species is prevalent in the field of 3D genomics. However, what exactly is meant by 'highly conserved' and what are the actual comparative data that support this notion? To address these questions, we performed a historical review of the relevant literature and retraced numerous citation chains to reveal the primary data that were used as the basis for the widely accepted conclusion that TADs are highly conserved across evolution. A thorough review of the available evidence suggests the answer may be more complex than what is commonly presented.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120795PMC
http://dx.doi.org/10.1016/j.tig.2020.10.009DOI Listing

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