ClinicalTrials.gov identifier: NCT02087137.
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Cancer cells within tumors exhibit a wide range of phenotypic states driven by non-genetic mechanisms in addition to extensively studied genetic alterations. Conversions among cancer cell states can result in intratumoral heterogeneity which contributes to metastasis and development of drug resistance. However, mechanisms underlying the initiation and/or maintenance of such phenotypic plasticity are poorly understood.
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Resource availability should have consequences for life-history functions and trade-offs among them because it influences the amounts of resources allocated to different functions. Nutritional status during a key developmental window (sexual maturation) may also have an important impact on life-history functions and such trade-offs. However, less is known about whether and how they interact to influence the resource allocation of individuals.
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