DoE Analysis of Approaches for Hydrogel Microbeads' Preparation by Millifluidic Methods.

Micromachines (Basel)

Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, Italy.

Published: November 2020

Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the preparation and characterization of highly controlled and reproducible microbeads made by different types of hydrogel using millifluidic approaches. The optimization of the process was made by a design of experiments (DoE) approach. The microbeads' large-scale production can be potentially used for single cells or clusters encapsulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697668PMC
http://dx.doi.org/10.3390/mi11111007DOI Listing

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