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Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy.
Front Biosci (Landmark Ed)
December 2024
Pathology Advanced Translational Research Unit, Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Background: Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, but their dynamics are altered in a subset of people living with Human Immunodeficiency Virus (HIV) known as immunological non-responders (INRs). INRs fail to reconstitute CD4 T-cell counts despite viral suppression. This study aimed to examine Treg dysregulation in INRs, comparing them to immunological responders (IRs) and healthy controls (HCs).
View Article and Find Full Text PDFThe trajectory of wetland change in China between 1980 and 2020: hidden losses and restoration effects.
Sci Bull (Beijing)
December 2024
State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China. Electronic address:
Understanding wetland change is critical to establishing and implementing international conservation and management conventions. With such knowledge, supporting sustainable development, making management decisions, improving policies, and conducting scientific research become possible. However, consistent information on changes in Chinese wetlands has been unavailable.
View Article and Find Full Text PDFChallenges and Lessons Learned in Managing Web-Based Survey Fraud for the Garnering Effective Outreach and Research in Georgia for Impact Alliance-Community Engagement Alliance Survey Administrations.
JMIR Public Health Surveill
December 2024
Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, United States.
Background: Convenience, privacy, and cost-effectiveness associated with web-based data collection have facilitated the recent expansion of web-based survey research. Importantly, however, practical benefits of web-based survey research, to scientists and participants alike, are being overshadowed by the dramatic rise in suspicious and fraudulent survey submissions. Misinformation associated with survey fraud compromises data quality and data integrity with important implications for scientific conclusions, clinical practice, and social benefit.
View Article and Find Full Text PDFThe Implementation and Outcomes of Personalized Antihypertensive Therapy Based on Pharmacogenetic Testing: A Retrospective Study Examining Blood Pressure Control and Medication Tolerability.
Cureus
November 2024
Medicine Department, Khyber Medical University, Peshawar, PAK.
Background: Hypertension management typically relies on standardized treatment regimens, which may not account for individual genetic variations that affect drug metabolism and response.
Objective: The objective of this study was to evaluate the effectiveness of personalized antihypertensive therapy, guided by pharmacogenetic testing, in terms of blood pressure (BP) control and medication tolerability.
Materials And Methods: A retrospective cohort study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from January 2023 to December 2023.
Agronomic biofortification of genetically biofortified wheat genotypes with zinc, selenium, iodine, and iron under field conditions.
Front Plant Sci
December 2024
Faculty of Engineering and Natural Sciences, Sabanci University Orta, Istanbul, ;Türkiye.
Inherently low concentrations of zinc (Zn), iron (Fe), iodine (I), and selenium (Se) in wheat ( L.) grains represent a major cause of micronutrient malnutrition (hidden hunger) in human populations. Genetic biofortification represents a highly useful solution to this problem.
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