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High-dose vitamin D administration and resistance exercise training attenuate the progression of obesity and improve skeletal muscle function in obese p62-deficient mice. | LitMetric

High-dose vitamin D administration and resistance exercise training attenuate the progression of obesity and improve skeletal muscle function in obese p62-deficient mice.

Nutr Res

Department of Nutrition, Food and Exercise Sciences, Florida State University, 120 Convocation Way, Tallahassee, FL 32306; The Center for Advancing Exercise and Nutrition Research on Aging, Florida State University, Tallahassee, 120 Convocation Way, Tallahassee, FL 32306. Electronic address:

Published: December 2020

AI Article Synopsis

  • Vitamin D (VitD) has potential benefits in reducing obesity-related health issues, particularly insulin resistance, inflammation, and muscle loss in p62-deficient mice.
  • A study tested four treatment groups, including a control, VitD alone, resistance training (RT) alone, and a combination of both, over a 10-week period.
  • Results showed that VitD helped maintain muscle function, but improved systemic insulin sensitivity and reduced inflammation only occurred with resistance training.

Article Abstract

Vitamin D (VitD) possesses antiadipogenic and ergogenic properties that could be effective to counteract obesity-related adverse health consequences. Therefore, our overall hypothesis was that VitD could ameliorate obesity-induced insulin resistance, systemic inflammation, and loss of skeletal muscle mass and function in an obesity animal model, p62-deficient mice. Furthermore, it was hypothesized that resistance exercise training (RT) could enhance the benefits of VitD by upregulating protein expression of vitamin D receptor in skeletal muscle. Forty 24-week-old male p62-deficient mice were assigned to the following 4 groups (10/group) for a 10-week intervention: control (p62C, no treatment), VitD (VD, 1000 IU vitamin D/kg/d), RT (ladder climbing, 3 times per week), or combined treatment (VRT, VD + RT). Serum VitD levels increased in VD and VRT (P < .05). Total body mass increased in p62C, VD, and VRT, but fat mass increased only in p62C (P < .05). Loss of skeletal muscle function was reported only in p62C (P < .05). Improved blood glucose levels and lower spleen mass were reported in RT and VRT compared to p62C (P < .05). However, the hindlimb muscle wet weights; myofiber cross-sectional area; and expression levels of the regulatory proteins for insulin signaling, inflammation, and muscle growth were not changed by any intervention. In conclusion, VitD administration attenuated the progression of obesity and preserved skeletal muscle function in p62-deficient mice. However, the obese mice improved systemic insulin sensitivity and inflammation only when the intervention involved RT.

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Source
http://dx.doi.org/10.1016/j.nutres.2020.10.002DOI Listing

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