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[Autosomal dominant intellectual developmental disorder 60 with seizures: a case report].
Zhongguo Dang Dai Er Ke Za Zhi
December 2024
Department of Neurology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, China.
The patient is a 10-month and 21-day-old girl who began to show developmental delays at 3 months of age, with severe language developmental disorders, stereotyped movements, and easily provoked laughter. Physical examination revealed fair skin and a flattened occiput. At 10 months of age, a video electroencephalogram suggested atypical absence seizures, with migrating slow-wave activity observed during the interictal period.
View Article and Find Full Text PDFPrevalance of Non-Provoke Generalize Tonic-Clonic Seizure in Sporadic Alzheimer's Disease.
J Epilepsy Res
December 2024
Department of Neurology, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Background And Purpose: Alzheimer's disease (AD) and epileptic seizure are among the most common health problems in the elderly population. This study aimed to estimate the prevalence rate and predictors of seizures in sporadic AD patients.
Methods: The study was conducted by retrospectively for a period of 10 years examining the file records.
Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children.
Pediatr Neurol
November 2024
Division of Rehabilitation Psychology Neuropsychology, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan. Electronic address:
Background: Neonatal seizures are common with acute brain injury. Up to 25% of survivors develop postneonatal epilepsy. We hypothesized postneonatal epilepsy diagnosed by age 24 months would increase risk for early markers of neurobehavioral disorders than acute provoked neonatal seizures alone.
View Article and Find Full Text PDFInhibition of the Integrated Stress Response Prevents Natural Forgetting and Corrects Accelerated Forgetting Associated with Epilepsy.
Mol Neurobiol
December 2024
Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, 541199, Guangxi, China.
The neural mechanisms underlying the natural and maladaptive forgetting of established memory remain largely unknown. Brain disease states might hijack the physiological forgetting mechanisms, resulting in maladaptive forgetting such as accelerated forgetting that contributes to cognitive decline in various neurologic conditions including epilepsy. Based on the key role of the integrated stress response (ISR) in memory storage and maintenance, we determined whether the ISR underpins natural and accelerated forgetting.
View Article and Find Full Text PDFChild Neurology: Neurophysiologic and Anatomical Correlates in Startle Epilepsy: A Comprehensive SEEG Investigation for Successful Resective Surgery.
Neurology
January 2025
From the Department of Neurological Surgery (J.K., S.H.H.), Asan Medical Center; and Department of Pediatrics (M.-J.K., M.-S.Y., T.-S.K.), Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.
Startle epilepsy, characterized by startle-provoked epileptic seizures, was historically recognized as one of the reflex epilepsies but currently lacks classification as a specific epileptic syndrome because of insufficient characterization. This study presents an institutional experience and review of relevant literature focusing on the neurophysiologic and anatomical aspects of startle epilepsy. We describe a pediatric patient with an underlying structural etiology of left frontal encephalomalacia who continued to experience disabling seizures despite multiple antiseizure medications and previous palliative surgery.
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