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Quantum computing for swarm robotics: a local-to-global approach.
Philos Trans A Math Phys Eng Sci
January 2025
ICAR, National Research Council (CNR), Palermo, Italy.
Quantum computing is a branch of computer science derived from the fundamental laws of quantum mechanics, such as state superposition, multi-value logic and destructive measure. An open challenge in itself is to re-think in quantum terms classic problems and solving techniques. Another nature-inspired field is the development of swarm-based robotic applications, where the challenge is catching the fundamental laws governing swarm dynamics, such as pattern formation and target reaching.
View Article and Find Full Text PDFRethinking Optimal Immunogens to Face SARS-CoV-2 Evolution Through Vaccination.
Influenza Other Respir Viruses
January 2025
Área de Investigación en Vacunas, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Valencia, Spain.
SARS-CoV-2, which originated in China in late 2019, quickly fueled the global COVID-19 pandemic, profoundly impacting health and the economy worldwide. A series of vaccines, mostly based on the full SARS-CoV-2 Spike protein, were rapidly developed, showing excellent humoral and cellular responses and high efficacy against both symptomatic infection and severe disease. However, viral evolution and the waning humoral neutralizing responses strongly challenged vaccine long term effectiveness, mainly against symptomatic infection, making necessary a strategy of repeated and updated booster shots.
View Article and Find Full Text PDFAddressing the concept of total pain in palliative care: A postcolonial South African hospice view.
Palliat Support Care
January 2025
Department of Psychology, Stellenbosch University, Stellenbosch, South Africa.
Objectives: Palliative care, which was formally established in the Global North, is now recognized globally as part of health care. As part of a larger study, we were interested in how decision-makers at a leading hospice in South Africa understood the changing local context and its influence on the delivery of services. We were interested in how the concept of "total pain," as outlined by Saunders, applies in a very unequal and under-resourced society in the shadow of a long, oppressive colonial, and apartheid past.
View Article and Find Full Text PDFRethinking retinoic acid self-regulation: A signaling robustness network approach.
Curr Top Dev Biol
January 2025
Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology and Genomic Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address:
All-trans retinoic acid (ATRA) signaling is a major pathway regulating numerous differentiation, proliferation, and patterning processes throughout life. ATRA biosynthesis depends on the nutritional availability of vitamin A and other retinoids and carotenoids, while it is sensitive to dietary and environmental toxicants. This nutritional and environmental influence requires a robustness response that constantly fine-tunes the ATRA metabolism to maintain a context-specific, physiological range of signaling levels.
View Article and Find Full Text PDFUHPC Viability for Nuclear Storage Facilities: Synthesis and Critical Review of Durability, Thermal, and Nuclear Properties for Informed Mix Modifications.
Materials (Basel)
January 2025
Department of Civil and Environmental Engineering, University of Nevada, Reno, NV 89557, USA.
Spent nuclear fuel (SNF) from the United States' nuclear power plants has been placed in dry cask storage systems since the 1980s. Due to the lack of a clear path for permanent geological repository for SNF, consolidated and long-term storage solutions that use durable concrete and avoid current aging and licensing challenges are becoming indispensable. Ultra-high-performance concrete (UHPC) is a rapidly growing advanced concrete solution with superior mechanical and durability properties that can help realize future resilient nuclear storage facilities.
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