Background: During hemorrhagic shock and subsequent resuscitation, pathways reliant upon calcium such as platelet function, intrinsic and extrinsic hemostasis, and cardiac contractility are disrupted. The objective of this systematic review was to examine current literature for associations between pretransfusion, admission ionized hypocalcemia, and composite outcomes including mortality, blood transfusion requirements, and coagulopathy in adult trauma patients.
Methods: This review was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. We searched Ovid MEDLINE and grey literature from database inception till May 3, 2020. Case series and reports were excluded. Reference lists of appraised studies were also screened for articles that the aforementioned databases might not have captured. The Newcastle-Ottawa Scale was used to assess study quality.
Results: A total of 585 abstracts were screened through database searching and alternative sources. Six unique full-text studies were reviewed, of which three were excluded. Admission ionized hypocalcemia was present in up to 56.2% of the population in studies included in this review. Admission ionized hypocalcemia was also associated with increased mortality in all three studies, with increased blood transfusion requirements in two studies, and with coagulopathy in one study.
Conclusion: Hypocalcemia is a common finding in shocked trauma patients. While an association between admission ionized hypocalcemia and mortality, blood transfusion requirements, and coagulopathy has been identified, further prospective trials are essential to corroborating this association.
Level Of Evidence: Systematic review, level III.
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http://dx.doi.org/10.1097/TA.0000000000003027 | DOI Listing |
Am J Trop Med Hyg
January 2025
Department of Clinical Laboratory, Chongqing University Three Gorges Hospital, Chongqing, China.
Trichoderma is a widely distributed thermophilic fungus that grows on moist soil, fallen leaves, and rotten wood. It plays an important role in agricultural production, food processing, and soil. However, some forms of Trichoderma can infect humans.
View Article and Find Full Text PDFWorld J Emerg Surg
January 2025
Federation of Anesthesiology, Intensive Care Unit, Burns and Operating Theater, Percy Military Training Hospital, 2 Rue Lieutenant Raoul Batany, 92140, Clamart, France.
Background: To reduce the number of deaths caused by exsanguination, the initial management of severe trauma aims to prevent, if not limit, the lethal triad, which consists of acidosis, coagulopathy, and hypothermia. Recently, several studies have suggested adding hypocalcemia to the lethal triad to form the lethal diamond, but the evidence supporting this change is limited. Therefore, the aim of this study was to compare the lethal triad and lethal diamond for their respective associations with 24-h mortality in severe trauma patients receiving transfusion.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.
Background: Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The genus includes at least 16 identified species. Stutzerimonas nitrititolerans, previously known as Pseudomonas nitrititolerans, was initially isolated from a bioreactor.
View Article and Find Full Text PDFSurg Neurol Int
November 2024
Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Background: Gram-positive opportunistic bacteria of the species are responsible for a large spectrum of infections, such as pneumonia, skin infections, and more widespread conditions, including brain abscesses.
Case Description: A 67-year-old male patient suffered from headache, gait disorder, and vertigo for a week before admission to our department. An enhanced magnetic resonance imaging scan revealed a mediosagittal hyperintense infratentorial lesion with concomitant compression of the fourth ventricle.
Am J Vet Res
January 2025
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Objective: To determine the association between ionized calcium (iCa) and/or total magnesium (tMg) and the development of sepsis and to investigate whether iCa or tMg is associated with mortality in puppies with canine parvoviral enteritis (CPE).
Methods: 64 client-owned puppies with CPE were enrolled in this prospective cohort study. Serum iCa and tMg were measured daily from admission until death or discharge.
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