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Clinical and contrast-enhanced image features in the prediction model for the detection of small hepatocellular carcinomas. | LitMetric

Clinical and contrast-enhanced image features in the prediction model for the detection of small hepatocellular carcinomas.

J Cancer

Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.

Published: October 2020

AI Article Synopsis

  • The study focuses on identifying new radiological features and clinical characteristics to enhance early detection criteria for small hepatocellular carcinoma (HCC).
  • It involved asymptomatic patients with high HCC risk, analyzing solid nodules found through ultrasound and confirming diagnoses using imaging and biopsy techniques.
  • The findings highlighted several key predictors, including tumor size, age, liver cirrhosis, and specific imaging characteristics, aiding in the improved early diagnosis of HCC in high-risk patients.

Article Abstract

: To identify novel radiological features and clinical characteristics to improve diagnostic criteria for early detection of small hepatocellular carcinoma (HCC). : We retrospectively recruited asymptomatic patients with no history of HCC but a high risk of HCC in whom a new, solitary, well-defined, solid nodule between 10 and 20 mm was detected through a screening ultrasound. We retrospectively collected all clinical data, and patients were examined using dynamic contrast-enhanced computed tomography or magnetic resonance imaging; subsequently, fine-needle biopsy was performed. A multivariate analysis of the predictors of small HCCs was performed by fitting a multiple logistic regression model with the stepwise variable selection method. : In total, 392 and 347 patients with a small liver nodule received a final pathologic confirmation of HCC and non-HCC, respectively. The estimated odds ratios and 95% confidence intervals of tumor size > 12.45 mm, age > 56.61 years, liver cirrhosis, hepatitis C virus (HCV) carrier status, ln alpha-fetoprotein (AFP) > 1.954, arterial phase enhancement, and portal or venous phase washout appearance without arterial phase enhancement were 2.0735 (1.4746-2.9155), 1.8878 (1.2949-2.7521), 1.6927 (1.1294-2.5369), 1.6186 (1.0347-2.5321), 2.0297 (1.3342-3.0876), 3.7451 (2.3845-5.8821), and 2.0327 (1.3500-3.0608), respectively. The area under the receiver operating characteristic curves for the diagnosis of small HCCs was 0.79 for arterial phase enhancement and 0.75 for portal or venous phase washout appearance without arterial phase enhancement. : Clinical and contrast-enhanced image features are valuable in the prediction model for the detection and early diagnosis of small HCCs in patients with a high risk of HCC. In addition to negative portal or venous washout and negative arterial enhancement in images, age > 56.61 years, tumor size > 12.45 mm, HCV carrier status, and ln(AFP) > 1.954, are useful indicators for the early detection of small HCCs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646160PMC
http://dx.doi.org/10.7150/jca.47245DOI Listing

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