AI Article Synopsis
- Venous thromboembolism (VTE) is a complex disease influenced by multiple factors, particularly inflammation, which can lead to a pro-thrombotic state.
- Anticoagulant medications, like low-molecular-weight heparins (LMWH) and direct oral anticoagulants (DOACs), are key treatments for VTE, with LMWH also lowering inflammatory markers like interleukin (IL)-6.
- A study found that DOACs reduced IL-6 levels in patients with deep vein thrombosis (DVT) compared to controls, suggesting that their anti-inflammatory effects may contribute to their treatment efficacy in VTE.
Article Abstract
Multiple factors play a pathophysiologic role for the venous thromboembolism (VTE) as a multi-factorial disease. Inflammation might play a peculiar role in shifting towards a pro-thrombotic state. Anticoagulant drugs are the first cure line for VTE. The low-molecular-weight heparins (LMWH) show anti-coagulant capability as well as reducing levels of inflammatory factors, including interleukin (IL)-6. The direct oral anticoagulants (DOACs) have shown efficacy in threating VTE, additionally to the anti-activated factor X these drugs seem able to reduce the abnormal release of pro-inflammatory agents. The present study evaluated the capability of DOACs in reducing plasma level of IL-6 in patients suffered from deep vein thrombosis (DVT) of the lower limbs. Our results showed reduced IL-6 expression levels in the peripheral lymphocytes of DVT compared to controls (fold-change, 2.8; P<0.05). We postulate that lowered IL-6 expression in the lymphocytes of DVT patients may mediate the anti-inflammatory action of DOACs. The present study is the first evidence concerning the anti-inflammatory properties of DOACs in specific setting of VTE patients such as DVT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646697 | PMC |
| http://dx.doi.org/10.3892/etm.2020.9367 | DOI Listing |
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