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| http://dx.doi.org/10.3389/fpls.2020.601021 | DOI Listing |
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Improving Outcome in Patients With Tricuspid Regurgitation: Look At the Kidneys and the Liver!
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Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA; Baylor Scott and White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA.
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Front Immunol
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Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany.
Melanoma is a metastatic, drug-refractory cancer with the ability to evade immunosurveillance. Cancer immune evasion involves interaction between tumor intrinsic properties and the microenvironment. The transcription factor E2F1 is a key driver of tumor evolution and metastasis.
View Article and Find Full Text PDFPancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains.
Front Endocrinol (Lausanne)
November 2024
Department of Cancer Biology and Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, CA, United States.
Introduction: Double C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and platelets, a phenotype also observed in a mouse model of T1D. Thus, DOC2B levels could provide important information on β-cell dys(function).
View Article and Find Full Text PDFtransfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA/J × DBA/2 abortion model.
Front Immunol
October 2024
Reproductive Immunology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Article Synopsis
- Inadequate decidualization in the endometrium can lead to negative pregnancy outcomes, including miscarriages, particularly in specific mouse strains (CBA/J mating with DBA/2).
- Researchers performed experiments by decidualizing endometrial stromal cells (ESCs) from CBA/J mice and tested their impact on pregnancy when implanted in female mice prior to mating.
- Results indicated that perfusing decidualized ESCs reduced pregnancy loss rates to match control groups but did not affect other reproductive metrics, highlighting the complexity of immune and tissue interactions in pregnancy success.
Increased peritoneal TGF-β1 is associated with ascites-induced NK-cell dysfunction and reduced survival in high-grade epithelial ovarian cancer.
Front Immunol
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Laboratory of Hematology - Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.
Natural killer (NK) cell therapy represents an attractive immunotherapy approach against recurrent epithelial ovarian cancer (EOC), as EOC is sensitive to NK cell-mediated cytotoxicity. However, NK cell antitumor activity is dampened by suppressive factors in EOC patient ascites. Here, we integrated functional assays, soluble factor analysis, high-dimensional flow cytometry cellular component data and clinical parameters of advanced EOC patients to study the mechanisms of ascites-induced inhibition of NK cells.
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