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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604263 | PMC |
| http://dx.doi.org/10.3389/fimmu.2020.595289 | DOI Listing |
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The field of reproductive biology has made significant progress in recent years, identifying specific molecular players that influence oocyte development and function. Among them, sirtuin 3 (SIRT3) has attracted particular attention for its central role in mediating mitochondrial function and cellular stress responses in oocytes. So far, studies have demonstrated that the knockdown of SIRT3 leads to a decrease in blastocyst formation and an increase in oxidative stress within an embryo, underscoring the importance of SIRT3 in maintaining the cellular redox balance critical for embryonic survival and growth.
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NSP1 allies with GSK3 to inhibit nodule symbiosis.
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Article Synopsis
- Salt stress negatively affects nitrogen fixation in legumes by decreasing nodule number, weight, and nitrogenase activity.
- A study by He et al. indicates that glycogen synthase kinase 3 (GSK3) plays a role in this process by phosphorylating nodulation signaling pathway 1 (NSP1).
- This phosphorylation reduces NSP1's ability to bind to DNA, leading to decreased nodulation in response to salt stress.
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