The decoy effect arises when the ratio of choosing B from A and B options is lower than the ratio of choosing B from A, B, and D options, wherein D is dominated by B. This decision pattern is obviously unreasonable but quite common. Previous research suggested that impulsive people have stronger decoy effect. Rs806379, as a single-nucleotide polymorphism (SNP) locus of cannabis receptor 1 gene (), has significant effect on impulsivity-people of A/A genotype are more impulsive than others. Therefore, rs806379 may relate to the decoy effect, which was tested in this study. Participants (359 Han Chinese college students) finished a task of the decoy effect, in which they made decisions between two or three mobile hard disks with various prices and provided saliva for genotyping. The results revealed the existence of the decoy effect. Furthermore, we found that participants with A/A genotype (251 Han Chinese college students) showed stronger decoy effect than others, when the prices were not high. This is the first attempt to study the decoy effect from a gene perspective. The result shows that even an SNP of a gene can have a significant association with complex human economic decision-making activities.
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http://dx.doi.org/10.3389/fpsyg.2020.523299 | DOI Listing |
Mol Plant Microbe Interact
January 2025
USDA-ARS Crop Production and Pest Control Research Unit, West Lafayette, Indiana, United States;
Most plant pathogens secrete effector proteins to circumvent host immune responses, thereby promoting pathogen virulence. One such pathogen is the fungus , which causes Fusarium Head Blight (FHB) disease on wheat and barley. Transcriptomic analyses revealed that expresses many candidate effector proteins during early phases of the infection process, some of which are annotated as proteases.
View Article and Find Full Text PDFOncologist
January 2025
HonorHealth Research Institute, Scottsdale, AZ, United States.
Lessons Learned: Intravenous paricalcitol did not improve the efficacy of pembrolizumab, likely related to the short half-life.
Background: Immunotherapy has limited benefit in the treatment of advanced pancreatic cancer with the tumor microenvironment playing a key role in immune resistance. In preclinical studies, vitamin D receptor (VDR) agonists have been shown to sensitize pancreatic tumors to PD-1 blockade.
J Proteome Res
January 2025
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany.
The first step in bottom-up proteomics is the assignment of measured fragmentation mass spectra to peptide sequences, also known as peptide spectrum matches. In recent years novel algorithms have pushed the assignment to new heights; unfortunately, different algorithms come with different strengths and weaknesses and choosing the appropriate algorithm poses a challenge for the user. Here we introduce PeptideForest, a semisupervised machine learning approach that integrates the assignments of multiple algorithms to train a random forest classifier to alleviate that issue.
View Article and Find Full Text PDFAdv Mater
January 2025
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao, 266071, China.
Corneal neovascularization (CorNV) develops under various pathological conditions and is one of the main causes of blindness. Due to that CorNV progression involves multiple steps, anti-vascular endothelial growth factor (VEGF) drugs alone could not sufficiently suppress this process, highlighting an urgent need for an efficient delivery system for the multi-step management of CorNV. In this study, a neutrophil nanovesicle-based eye drop (NCCR) is developed for CorNV therapy that simultaneously inhibits angiogenesis and inflammation, while eliminating pathological cells through chemoexcited photodynamic therapy (PDT).
View Article and Find Full Text PDFArtif Organs
January 2025
Laboratory for Immune Response and Regulatory Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Background: The pathogenesis of sepsis is thought to be linked to a dysregulated immune response, particularly that involving neutrophils. We have developed a granulocyte adsorption column as a "decoy organ," which relocates the massive inflammation in organs in the body to a blood purification column. This study was conducted to assess the safety and experimental effectiveness of granulocyte monocyte adsorption apheresis-direct hemoperfusion (G1-DHP) in the treatment of patients with sepsis, using a prospective, multicenter design.
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