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| http://dx.doi.org/10.3389/fphys.2020.592856 | DOI Listing |
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MG53's non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues.
Front Endocrinol (Lausanne)
October 2024
Division of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, United States.
Article Synopsis
- MG53 is known for its role in tissue repair and reducing inflammation, but its potential impact on type 2 diabetes is debated.
- This study investigates whether MG53 affects insulin signaling in various tissues by examining its binding to the insulin receptor and its effects on insulin-stimulated signaling in cells and mice.
- The results suggest that while MG53 can bind to the insulin receptor, its interaction is weak and not physiologically relevant, challenging the idea that increasing MG53 could be a new treatment for type 2 diabetes.
Editorial: Integrative exercise endocrinology.
Front Endocrinol (Lausanne)
January 2024
Centre of Inflammation and Metabolism/Centre for Physical Activity Research, University of Copenhagen, Copenhagen, Denmark.
Special Issue "Adipokines, Myokines, and Physical Exercise in Health and Disease 2.0".
Int J Mol Sci
January 2024
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland.
We are pleased to present our Editorial to this Special Issue on "Adipokines, Myokines, and Physical Exercise in Health and Disease 2 [...
View Article and Find Full Text PDFInterleukin-15 responses to acute and chronic exercise in adults: a systematic review and meta-analysis.
Front Immunol
January 2024
Institute of Human Movement and Sports Engineering, Zhejiang Normal University, Jinhua, Zhejiang, China.
Purpose: Interlukin-15 (IL-15) is an inflammatory cytokine that plays a vital role in immunology and obesity-associated metabolic syndrome. We performed this systematic review and meta-analysis to investigate whether exercise promotes circulating IL-15 concentrations in adults.
Methods: We searched PubMed, Web of Science, and Scopus from inception to May, 2023 and identified original studies that investigated the effectiveness of acute and/or chronic exercise on serum/plasma IL-15 levels in adults.
Mouse skeletal muscle adaptations to different durations of treadmill exercise after the cessation of FOLFOX chemotherapy.
Front Physiol
November 2023
Integrative Muscle Biology Laboratory, Division of Regenerative and Rehabilitative Sciences, University of Tennessee Health Science Center, Memphis, TN, United States.
FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is a treatment for colorectal cancer that can induce persistent fatigue and metabolic dysfunction. Regular exercise after chemotherapy cessation is widely recommended for cancer patients and has been shown to improve fatigue resistance in mice. However, gaps remain in understanding whether the early systemic and skeletal muscle adaptations to regular exercise are altered by prior FOLFOX chemotherapy treatment.
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