Objective: To investigate the imaging findings and pathological features, differential diagnosis of esophageal sarcomatoid carcinoma.
Methods: Three cases of esophageal sarcomatoid carcinoma (ESC) proved by histology was retrospectively analyzed, and related literature were reviewed.
Results: Two cases of barium in the digestive tract showed an irregular filling defect in the thoracic esophagus. The edges are clear, the surface of the tumor is irregular, and the niche is visible. The long axis of the tumor is the same as the esophagus, esophageal expansion, and the mucosa of the lesion area is destroyed. CT scan of 1 case showed a ellipse-like pedicle solid mass in the lower esophagus, the pedicle, and back wall is linked together, the back wall is slight thick, and esophageal eccentric stenosis, homogeneous density, lesions showed moderate enhancement, and the peripheral enhancement was relatively obvious in the central region, and the pedicle was not clear with the right posterior wall of esophagus. Intraoperative observation showed that the tumor was solid, rubbery, and the pedicle was closely related to the right posterior wall of esophagus. All 3 cases were pathologically diagnosed as esophageal sarcomatoid carcinoma.
Conclusion: ESC is uncommon, the imaging features have some characteristics, accurate diagnosis depends on the pathological examination.
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http://dx.doi.org/10.1177/1179547620959066 | DOI Listing |
Front Oncol
August 2024
Department of Thoracic Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Front Oncol
July 2024
Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Introduction: Esophageal sarcomatoid carcinoma (ESC) is a rare pathological subtype of esophageal carcinomas, wherein its epithelial component typically demonstrates squamous cell carcinoma (SCC). However, the clinicopathological features and prognosis of ESC remain unclear, alongside its unique aspects compared to esophageal SCC (ESCC).
Methods: Between January 2008 and December 2018, we retrospectively reviewed 67 ESC patients treated at West China Hospital.
Zhonghua Bing Li Xue Za Zhi
March 2024
Ningbo Clinical Pathology Diagnosis Center, Ningbo 315021, China.
To investigate the clinicopathological features and molecular genetic characteristics of esophageal carcinoma with ductal differentiation, and to summarize the experiences in its diagnosis and treatment. A total of 17 cases of esophageal carcinoma with ductal differentiation diagnosed in Ningbo Clinical Pathological Diagnosis Center, Ningbo, China from June 2011 to December 2022 were collected. The clinical information and pathological diagnosis was reviewed.
View Article and Find Full Text PDFLancet Gastroenterol Hepatol
April 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Background: The aim of the COSMIC-312 trial was to evaluate cabozantinib plus atezolizumab versus sorafenib in patients with previously untreated advanced hepatocellular carcinoma. In the initial analysis, cabozantinib plus atezolizumab significantly prolonged progression-free survival versus sorafenib. Here, we report the pre-planned final overall survival analysis and updated safety and efficacy results following longer follow-up.
View Article and Find Full Text PDFCureus
October 2023
Radiation Oncology, Great Eastern Medical School and Hospital, Srikakulam, IND.
Sarcomatoid carcinoma of the esophagus, a mixed tumor comprising both carcinomatous and sarcomatoid components and known as carcinosarcoma, is a rare malignancy. Clinically and radiologically, it presents like other esophageal cancers. Here we discuss the case of a 69-year-old male patient with sarcomatoid carcinoma of the esophagus who developed Stevens-Johnson syndrome (SJS) after chemotherapy with carboplatin and paclitaxel.
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