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Pharmacokinetics, pharmacodynamics, safety, and tolerability of dopamine-receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting.
Expert Opin Drug Metab Toxicol
June 2024
Department of Clinical Oncology, Zealand University Hospital Roskilde, Roskilde, Denmark.
Introduction: Dopamine (D)-receptor antagonists (RAs) were the first antiemetics used in the prophylaxis of chemotherapy-induced nausea and vomiting (CINV).
Areas Covered: Eight D-RAs, amisulpride, domperidone, droperidol, haloperidol, metoclopramide, metopimazine, olanzapine and prochlorperazine are reviewed focusing on pharmacokinetics, pharmacodynamics, antiemetic effect and side effects.
Expert Opinion: Since the introduction of D-RAs, antiemetics such as corticosteroids, 5-hydroxytryptamine (5-HT)-RAs and neurokinin (NK)-RAs have been developed.
Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study.
BMJ
March 2022
Univ. Bordeaux, INSERM, BPH, team Pharmacoepidemiology, U1219, Bordeaux, France.
Objective: To estimate the risk of ischaemic stroke associated with antidopaminergic antiemetic (ADA) use.
Design: Case-time-control study.
Setting: Data from the nationwide French reimbursement healthcare system database Système National des Données de Santé (SNDS).
What changes in prescription patterns of antiemetic medications in pregnant women in France?
Fundam Clin Pharmacol
December 2021
Réseau REGARDS, Laboratoire de Pharmacologie Médicale et Clinique (Medical and Clinical Pharmacology Laboratory), Centre Hospitalier Universitaire de Toulouse (Toulouse University Hospital Center), CERPOP INSERM UMR 1295, Faculté de Médecine de Toulouse (Toulouse Faculty of Medicine), Toulouse, France.
Background: In France, few data are available on the prescription patterns of antiemetic medications in pregnant women.
Objectives: The purpose of this study was to describe antiemetic medication prescriptions and trends over time. Can we observe significant changes in pregnant woman prescriptions in recent years?
Methods: We conducted a drug utilization study among pregnant women using data from the EFEMERIS database, including 135 574 pregnant women who had a pregnancy outcome between 2004 and 2017 in Haute-Garonne (France).
From domperidone to metopimazine: Anticipating the media impact of pharmacovigilance announcements.
Therapie
March 2022
Inserm, UMR-S1172, Center for Pharmacovigilance, CHU de Lille, University Lille, 59037 Lille, France.
The evolution of anti-emetic prescriptions in primary care, between 2006 and 2016.
Pharmacoepidemiol Drug Saf
April 2021
Department of Family Medicine, Faculty of Health Sciences, Simone Veil, University of Versailles, Saint-Quentin-en-Yvelines, France.
Context: Serious adverse events related to the use of domperidone and metoclopramide have been consistently reported in the literature for many years. This led to a restriction of their use in the early 2010s.
Objective: The main objective was to analyse the evolution of antiemetic prescription rate in French general practise between 2006 and 2016.
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