AI Article Synopsis
- Hyperlipoproteinemia Type III (HLP3) is characterized by cholesterol and triglyceride-rich remnant lipoproteins, with diagnosis usually requiring complex serum ultracentrifugation, which isn't commonly available.
- The study aimed to optimize the triglyceride (TG) cutoff using the apoB algorithm for the identification of HLP3, analyzing data from 128,485 lipid profiles to assess various TG levels.
- The results indicated that a TG level of ≥ 133 mg/dL provides the best balance between sensitivity and specificity for screening HLP3, although higher TG cutoffs could identify more severe cases at the cost of reduced sensitivity.
Article Abstract
Background: Hyperlipoproteinemia Type III (HLP3), also known as dysbetalipoproteinemia, is defined by cholesterol and triglyceride (TG) enriched remnant lipoprotein particles (RLP). The gold standard for diagnosis requires demonstration of high remnant lipoprotein particle cholesterol (RLP-C) by serum ultracentrifugation (UC), which is not readily available in daily practice. The apoB algorithm can identify HLP3 using total cholesterol (TC), plasma triglyceride (TG), and apoB. However, the optimal TG cutoff is unknown.
Objective: We analyzed apoB algorithm defined HLP3 at different TG levels to optimize the TG cutoff for the algorithm.
Methods: 128,485 UC lipid profiles in the Very Large Database of Lipids (VLDbL) were analyzed. RLP-C was assessed at TG ≥ 133 mg/dL, ≥175 mg/dL, ≥200 mg/dL, and ≥ 250 mg/dL. Sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and prevalence adjusted and bias-adjusted kappa (PABAK) were calculated against UC Criterion (VLDL-C/TG ≥ 0.25) for HLP3.
Results: The median age (IQR) was 57 years (46-68). 45% were men, 20.1% had diabetes, and 25.5% had hypertension. The median RLP-C level for the TG cutoffs (mg/dL) of ≥ 133, ≥ 175, ≥ 200, and ≥ 250 were 34, 43, 50, and 62 mg/dL, respectively, compared to 67 mg/dL in UC defined HLP3. TG ≥ 133 mg/dL yielded optimal results (Sn 29.5%, Sp 98.5%, PABAK 0.96, PPV 13.6%, NPV 99.4%).
Conclusion: TG ≥ 133 mg/dL allows for high sensitivity in screening for HLP3. Higher TG cutoffs may identify more severe HLP3 phenotypes, but with a large loss in sensitivity for HLP3.
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| http://dx.doi.org/10.1016/j.jacl.2020.09.011 | DOI Listing |
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