Introduction: Avascular necrosis of the bone is a very common finding in sickle cell disease (SCD). The malignant transformation of a pre-existing bone infarct is extremely rare, only few cases has been reported related to different etiologies one of which is SCD.

Presentation Of Case: 40 years old male, known to have SCD, he presented as a case of avascular necrosis of the left proximal femur. Upon further investigations the lesion has transformed into undifferentiated pleomorphic sarcoma also known as Malignant Fibrous Histiocytoma (MFH).

Discussion: The exact mechanism of the malignant transformation of bone infarcts is not fully understood and yet to be investigated. Few cases were reported in literature of similar malignant transformation of a pre-exciting bone infarct and only one was linked to SCD.

Conclusion: In reporting this case we hope that further cases worldwide will be reported. A high index of suspicion should be present when encountering bone infarct lesion with an unusual course.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672249PMC
http://dx.doi.org/10.1016/j.ijscr.2020.11.004DOI Listing

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