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Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis.
Nat Commun
January 2025
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Myeloproliferative neoplasm-associated myelofibrosis is a clonal stem cell process characterized by pronounced bone marrow fibrosis associated with extramedullary hematopoiesis and splenomegaly. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment leading to bone marrow fibrosis regression. Here we provide an in-depth skeletal characterization of myelofibrosis patients before and after allo-HSCT utilizing clinical high-resolution imaging, laboratory analyses, and bone biopsy studies.
View Article and Find Full Text PDFEvolving glacier patterns in the Chenab River Basin (1993-2021): Drivers and environmental implications.
Sci Total Environ
January 2025
Ministry of Earth Science, New Delhi 110003, India.
Glaciers of Jammu and Kashmir are retreating faster than those in the broader northwestern Himalayas, yet some glaciers in the Chenab River basin display signs of periodic advancement and mass gain (2005-2007). These features, such as coalescing lobate structures and blocked meltwater streams, raise intriguing questions about localized glacier dynamics. While global concerns over climate change and glacier retreat persist, the lack of detailed evidence regarding glacier advance in this region warrants further investigation.
View Article and Find Full Text PDFBCL6 Alleviates Hepatic Ischemia/Reperfusion Injury Via Recruiting SIRT1 to Repress the NF-κB/NLRP3 Pathway.
Transplantation
January 2025
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Background: Hepatic ischemia/reperfusion (I/R) injury (HIRI) is an intrinsic phenomenon observed in the process of various liver surgeries. Unfortunately, there are currently few options available to prevent HIRI. Accordingly, we aim to explore the role and key downstream effects of B-cell lymphoma 6 (BCL6) in hepatic I/R (HIR).
View Article and Find Full Text PDFSpin caloritronics as a probe of nonunitary superconductors.
Sci Adv
January 2025
Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803-4001, USA.
Superconducting spintronics explores the interplay between superconductivity and magnetism, sparking substantial interest in nonunitary superconductors as a platform for magneto-superconducting phenomena. However, identifying nonunitary superconductors remains challenging. We demonstrate that spin current driven by thermal gradients sensitively probes the nature of the condensate in nonunitary superconductors.
View Article and Find Full Text PDFThe Two-Spin Enigma: From the Helium Atom to Quantum Ontology.
Entropy (Basel)
November 2024
EPITA Research Laboratory, 14-16 Rue Voltaire, 94270 Le Kremlin-Bicêtre, France.
The purpose of this article is to provide a novel approach and justification of the idea that classical physics and quantum physics can neither function nor even be conceived without the other-in line with ideas attributed to, e.g., Niels Bohr or Lev Landau.
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