AI Article Synopsis
- The study investigates the link between body mass index (BMI) and gene expression in normal breast tissue, specifically looking at how obesity might influence breast cancer development.
- Two datasets of breast tissue specimens were analyzed, identifying nine genes whose expression varied with BMI, suggesting a correlation between obesity and inflammation-related gene activity.
- The findings imply that increased body fat could promote chronic inflammation in breast tissue, potentially contributing to breast cancer risk through the upregulation of inflammation-related genes.
Article Abstract
Background: In human breast, adipose tissue represents up to 80% of the total volume and plays a critical role in mammary gland remodeling. Given the emerging role of obesity in breast cancer growth and development, we explored the relationship between body mass index (BMI), as a proxy of woman's obesity status, and the expression in normal breast tissue from healthy women of a selected panel of genes, known to be involved in mammary gland homeostasis.
Methods: Two independent publicly available datasets, composed of 180 specimens of normal breast tissue from reduction mammoplasty were interrogated. Differential gene expression among BMI classes was evaluated by ANOVA, and partial correlation coefficient was used to assay the correlation between genes controlling for BMI.
Results: Despite the differences in microarray platforms and analytical procedures, the two datasets shared a core of 9 genes differentially expressed in BMI classes and significantly correlated with BMI. Four (44%) of these genes belong to the functional class of cytokines and cytokine receptors (IL1R1, IL2RA, IL12A, and IL12RB2). The others belong to the functional class of the epigenetic regulation (MEDAG and SETD7), signal transduction (STAT1), cell adhesion (ITGAV), and enzymatic activity (STS).
Conclusions: Although exploratory, present findings are in agreement with the role of inflammation modulators in the homeostasis of normal breast tissue and the believe that an increase in body adipose tissue may have a potentially dangerous local effect, through the increased expression of inflammation-related genes and the establishment of a low-grade chronic inflammation.
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| http://dx.doi.org/10.1007/s12282-020-01183-z | DOI Listing |
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