Autologous cell-based therapy for bone regeneration might be impaired by diabetes mellitus (DM) due to the negative effects on mesenchymal stem cells (MSCs) differentiation. Strategies to recover their osteogenic potential could optimize the results. We aimed to evaluate the effect of photobiomodulation (PBM) therapy on osteoblast differentiation of rats with induced DM. Bone marrow MSCs of healthy and diabetic rats were isolated and differentiated into osteoblasts (OB and dOB, respectively). dOB were treated with PBM therapy every 72 hour (660 nm; 0.14 J; 20 mW; 0.714 W/cm , and 5 J/cm ). Cell morphology, viability, gene and protein expression of osteoblastic markers, alkaline phosphatase (ALP) activity, and the mineralized matrix production of dOB-PBM were compared to dOB. PBM therapy improved viability of dOB, increased the gene and protein expression of bone markers, the ALP activity and the mineralized matrix production. PBM therapy represents an innovative therapeutic approach to optimize the treatment of bone defects in diabetic patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jbio.202000393 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of 850 nm LED irradiation on the alignment of crowded mandibular anterior teeth: a randomized controlled clinical trial.
Clin Oral Investig
December 2024
Department of Orthodontics, Faculty of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Introduction: This study aims to determine if intraoral 850 nm LED irradiation could reduce the duration of lower anterior crowding alignment.
Methods: In a parallel-designed, randomized controlled clinical trial 60 patients with 2 to 6 mm of lower incisor crowding who need non-extraction treatment, were randomly assigned to the intervention and control groups by block randomization (36 females, 24 males, mean age: 19.93 ± 3.
Photobiomodulation as part of multimodal analgesia to improve pain relief and wound healing after elective caesarean section: A protocol for randomized controlled trial.
PLoS One
December 2024
Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
Background: Caesarean section (CS) is the most common inpatient surgical procedure performed in Canada. CS is known to cause moderate-to-severe pain, which is suggested to be associated with postpartum depression and persistent pain. Existing limitations in multimodal analgesia and conscious attempts to avoid opioids highlight the need for non-pharmacological strategies.
View Article and Find Full Text PDF[Effect of low-intensity laser-therapy in the correction of encephalopathy in obstructive jaundice].
Vopr Kurortol Fizioter Lech Fiz Kult
December 2024
Polyclinic No. 3 of the Medical Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation, Moscow, Russia.
Unlabelled: Hepatic encephalopathy is an early and severe complication of obstructive jaundice and is characterized by occurrence of non-focal and focal neurological manifestations. Different methods of therapy are applied for disorder correction. Low-intensity laser blood irradiation has a pronounced antioxidant and vasoactive effect.
View Article and Find Full Text PDFCommentary on Clinical Safety and Efficacy of Dual Wavelength Low Level Light Therapy in Androgenetic Alopecia; A Double-Blind Randomized Controlled Study.
Dermatol Surg
December 2024
Dermatology, Weill Cornell Medical School, Private Practice, New York City; New York.
Photobiomodulation Therapy for Non-exudative Age-related Macular Degeneration.
Int Ophthalmol Clin
January 2025
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.
Age-related macular degeneration (AMD) is a chronic condition that causes gradual central vision loss, most commonly in patients 50 years or older. This disease is commonly classified as either dry (non-exudative) or wet (exudative). Most patients with AMD have the non-exudative form, characterized by the presence of drusen in the macula.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!