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Mechanistic exploration of Traditional Chinese Medicine regulation on tumor immune microenvironment in the treatment of triple-negative breast cancer: based on CiteSpace and bioinformatics analysis.
Front Immunol
January 2025
Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, characterized by frequent recurrence, metastasis, and poor survival outcomes despite chemotherapy-based treatments. This study aims to investigate the mechanisms by which Traditional Chinese Medicine (TCM) modulates the tumor immune microenvironment in TNBC, utilizing CiteSpace and bioinformatics analysis.
Methods: We employed CiteSpace to analyze treatment hotspots and key TCM formulations, followed by bioinformatics analysis to identify the main active components, targets, associated pathways, and their clinical implications in TNBC treatment.
A Rare Case of Metachronous Clear Cell Ovarian Carcinoma and Thyroid Carcinoma: Clinical and Pathological Insights.
Int J Womens Health
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Background: Clear cell ovarian carcinoma (CCOC) is a type of epithelial ovarian cancer, representing 5-11% of ovarian cancers. CCOCs tend to occur in the fifth to seventh decades of life, with only 10% of cases occurring in the fourth decade. On the other side, papillary thyroid carcinoma is the most common histology type of thyroid carcinoma and is associated with locoregional spread.
View Article and Find Full Text PDFA multivariable model of ultrasound and biochemical parameters for predicting high-volume lymph node metastases of papillary thyroid carcinoma with Hashimoto's thyroiditis.
Front Endocrinol (Lausanne)
January 2025
Department of Ultrasound Diagnosis, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Objectives: This study aims to develop a nomogram to predict high-volume (> 5) lymph node metastases (HVLNM) in papillary thyroid carcinoma concomitant with Hashimoto's thyroiditis by combining ultrasound with clinicopathologic data.
Materials And Methods: The study reviewed 187 patients diagnosed with papillary thyroid cancer (PTC) concomitant with Hashimoto's thyroiditis from the First People's Hospital of Kunshan between March 2018 and December 2022. These patients underwent preoperative ultrasound and postoperative examinations.
Is classic papillary thyroid carcinoma definitely an "indolent cancer"?-a case of locally advanced classic occult papillary thyroid carcinoma: a case report.
AME Case Rep
November 2024
Department of Oncology Surgery, Qinghai University Affiliated Hospital, Xining, China.
Background: Occult papillary thyroid carcinoma (PTC) refers to the PTC accidentally found due to its occult lesions. Classic, as the most common subtype of PTC, is usually considered to have a low degree of malignancy and a favorable prognosis. Currently, the American Thyroid Association Management Guidelines adopted active surveillance (AS) as an alternative to immediate surgery in some low-risk PTC patients with less than 1 cm in diameter.
View Article and Find Full Text PDFThe Predictive Value of a Nomogram Based on Ultrasound Radiomics, Clinical Factors, and Enhanced Ultrasound Features for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.
Ultrason Imaging
January 2025
Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
This study aims to establish and validate an ultrasound radiomics nomogram for preoperative prediction of central lymph node metastasis in papillary thyroid microcarcinoma (PTMC) before operation. A retrospective analysis conducted on ultrasonic images and clinical features derived from 288 PTMC patients, who were divided into training cohorts ( = 201) and validating cohorts ( = 87) in a ratio of 7:3 base on the principle of random allocation. Radiomics features were extracted from the PTMC patients after ultrasonic examination, followed by dimension reduction and characteristic selection to construct the radiomics score (Radscore) using LASSO regression analysis.
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