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The broad spectrum of clinical manifestations caused by peripheral arterial disease [PAD] and the morphologic heterogeneity of associated atherosclerotic lesions present a considerable management challenge. Endovascular interventions are recognized an effective treatment for PAD. Within this revascularization strategy the role of atherectomy debulking modalities continue to evolve.
View Article and Find Full Text PDFImpact of Complications on Survival Outcomes in Different Temporary Mechanical Circulatory Support Techniques: A Large Retrospective Cohort Study of Cardiac Surgical and Non-surgical Patients.
J Heart Lung Transplant
December 2024
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13353 Berlin, Germany; Deutsches Herzzentrum der Charité, Department of Cardiothoracic and Vascular Surgery, Berlin, Germany. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Background: Temporary mechanical circulatory support (tMCS) devices have become a standard treatment option in cardiogenic shock but are associated with high complication rates. This study analyzes common complications associated with modern tMCS devices and their impact on mortality depending on the tMCS approach.
Methods: We conducted a retrospective single-center analysis of patients with all-cause cardiogenic shock treated with veno-arterial extracorporeal life support, microaxial flow pump, and a combination of both (ECMELLA).
Successful surgical management of Leriche syndrome in a 30-year-old female patient: A rare case report.
Int J Surg Case Rep
December 2024
Department of Vascular Surgery, Faculty of Medicine, Aleppo University Hospital, University of Aleppo, Aleppo, Syria.
Introduction And Importance: Leriche syndrome (LS), or aortoiliac occlusive disease, is a rare form of peripheral arterial disease leading to claudication, impotence, and diminished femoral pulses due to atheromatous obstruction of the infrarenal aorta and common iliac arteries. Early identification is crucial as untreated LS can result in severe complications. Treatment primarily involves surgical interventions, with endovascular options considered as alternatives.
View Article and Find Full Text PDFHypoxia-induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation.
FEBS J
December 2024
School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Critical limb ischemia (CLI) is the most advanced stage of peripheral arterial disease, posing a high risk of mortality. Sphingomyelin, a sphingolipid synthesized by sphingomyelin synthases (SMSs) 1 and 2, plays an essential role in signal transduction as a component of lipid rafts. However, the role of sphingomyelin in the inflammation of ischemic skeletal muscles remains unclear.
View Article and Find Full Text PDFDisposable intravenous infusion sets as a temporary intravascular shunt for major limb replantation: a retrospective study.
Langenbecks Arch Surg
December 2024
Department of Plastic Reconstructive Surgery & Hand Microsurgery, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China.
Objective: The key to increasing the success rate of limb preservation lies in timely restoration of the blood supply to the severed limb, This study examines the clinical effect of a disposable intravenous infusion device as a temporary vascular shunt device which can quickly restore blood circulation in the replantation of severed limbs.
Methods: A retrospective review of all amputated major limbs in our department from May 2005 to May 2022. Patients treated with intravenous infusion tubes as temporary vascular shunt devices were included in group A(shunt group ) and those who could not use temporary intravascular shunt devices were included in group B (no shunt group).
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