Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.

Reprod Biol Endocrinol

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont Medical Center, Larner College of Medicine, 111 Colchester Ave, Burlington, VT, 05401, USA.

Published: November 2020

AI Article Synopsis

  • Increasing paternal age in developed countries is influenced by factors like delayed marriage, longer life expectancy, and better reproductive technologies.
  • Concerns arise regarding how older age affects sperm quality, success rates of assisted reproductive methods, and the health of children born to older fathers.
  • The review highlights the links between advanced paternal age and various issues related to sperm performance, reproductive success, and offspring health outcomes.

Article Abstract

Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664076PMC
http://dx.doi.org/10.1186/s12958-020-00668-yDOI Listing

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