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Diagnostic Value of Initial Chest CT Findings for the Need of ICU Treatment/Intubation in Patients with COVID-19. | LitMetric

Diagnostic Value of Initial Chest CT Findings for the Need of ICU Treatment/Intubation in Patients with COVID-19.

Diagnostics (Basel)

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Radiology, Charitéplatz 1, 10117 Berlin, Germany.

Published: November 2020

AI Article Synopsis

  • Computed tomography (CT) is crucial for diagnosing COVID-19 and this study aimed to develop a simple method for identifying patients who may need intensive care.
  • Researchers analyzed initial CT scans of 28 COVID-19 patients to classify the extent of lung damage using both subjective and semi-quantitative methods.
  • The results showed that a 10% increase in lung involvement significantly raised the risk of needing intubation and ICU admission, with the semi-quantitative measurement being more effective than subjective assessments for determining care needs.

Article Abstract

Computed tomography (CT) plays an important role in the diagnosis of COVID-19. The aim of this study was to evaluate a simple, semi-quantitative method that can be used for identifying patients in need of subsequent intensive care unit (ICU) treatment and intubation. We retrospectively analyzed the initial CT scans of 28 patients who tested positive for SARS-CoV-2 at our Level-I center. The extent of lung involvement on CT was classified both subjectively and with a simple semi-quantitative method measuring the affected area at three lung levels. Competing risks Cox regression was used to identify factors associated with the time to ICU admission and intubation. Their potential diagnostic ability was assessed with receiver operating characteristic (ROC)/area under the ROC curves (AUC) analysis. A 10% increase in the affected lung parenchyma area increased the instantaneous risk of intubation (hazard ratio (HR) = 2.00) and the instantaneous risk of ICU admission (HR 1.73). The semi-quantitative measurement outperformed the subjective assessment diagnostic ability (AUC = 85.6% for ICU treatment, 71.9% for intubation). This simple measurement of the involved lung area in initial CT scans of COVID-19 patients may allow early identification of patients in need of ICU treatment/intubation and thus help make optimal use of limited ICU/ventilation resources in hospitals.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696816PMC
http://dx.doi.org/10.3390/diagnostics10110929DOI Listing

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