is the main bacteria associated with gastroduodenal diseases. Recent studies have reported that gastric microbiota might be modified by the colonization, favoring gastric lesions' development. In Chile, the region of La Araucanía concentrates a high risk of gastric cancer associated with colonization, rurality, poverty, and Mapuche ethnicity. Hence, we aimed to identify the culturable gastric microbiota and characterize its variability at different stages of epithelial injury, based on its colonization in dyspeptic patients from this Chilean region. Microaerophilic bacteria strains were isolated from antrum biopsies of 155 dyspeptic patients' biopsies and identified using MALDI-TOF MS or gene sequencing for non-pylori species identification, and gene amplification for confirmation. We found 48 species from 18 families, mainly belonging to (21.3%), (20.0%), (9.0%), , and (4.5%); however, and families showed a significant reduction in samples infected with , along with a considerably lower diversity of species. Our results revealed a microbiota modification due to colonization associated with the gastric epithelial state, suggesting a potential microbiota role for developing and progressing gastric diseases.
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| http://dx.doi.org/10.3390/microorganisms8111763 | DOI Listing |
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