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Dominance of the ON1 Genotype of RSV-A and BA9 Genotype of RSV-B in Respiratory Cases from Jeddah, Saudi Arabia. | LitMetric

AI Article Synopsis

  • Human respiratory syncytial virus (HRSV) is a leading cause of hospital admissions for lower respiratory infections, with the study conducted in Jeddah revealing a 13.4% prevalence among respiratory cases.
  • From the analyzed cases, 64% were identified as group A (specifically the ON1 genotype), while 36% were group B (BA9 genotype), with notable genetic variations compared to previous studies in Saudi Arabia.
  • The differences in genotype prevalence in Jeddah versus Riyadh and Taif may result from global spread or increased traveler traffic, underscoring the need for continuous surveillance for respiratory infection genotypes to aid in vaccine development.

Article Abstract

Human respiratory syncytial virus (HRSV) is a main cause of hospital admission for lower respiratory tract infection. In previous studies from Saudi Arabia, higher prevalence of the NA1 genotype in group A was observed from Riyadh and Taif. This study recruited respiratory cases from Jeddah during January to December, 2017. RSV represented 13.4% in the recruited cases with 64% of them belonging to group A and 36% to group B. All group A cases in this study were ON1 type characterized by duplication of 72 nucleotides, 24 amino acids in the C-terminal in the second hypervariable region of the G gene. In addition, for group B all of the cases were clustered under BA9, which had uniquely characterized as duplication of 60 nucleotides in the G protein. Our sequences showed similarity with earlier sequences from Saudi Arabia, Kuwait, Thailand, South Africa, Spain, the USA and Cyprus. Some amino acid substitutions in the investigated sequences would cause a change in potential O-glycosylation and N-glycosylation profiles from prototype ON1. The predominance of the ON1 and BA9 genotype of RSV-A in Jeddah compared to previous Saudi studies showing predominance of the NA1 genotype for group A. This difference in genotype prevalence could be due to fast spread of the ON1 genotype worldwide or due to the flux of travelers through Jeddah during hajj/umrah compared to Riyadh and Taif. This shift in genotype distribution requires continuous surveillance for genetic characterization of circulating respiratory infections including RSV. These findings may contribute to the understanding of RSV evolution and to the potential development of a vaccine against RSV.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695323PMC
http://dx.doi.org/10.3390/genes11111323DOI Listing

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