, Tissue Viability Nurse Consultant, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool (julie.tyrer@lhch.nhs.uk), runner-up in the BJN Awards 2020.
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| http://dx.doi.org/10.12968/bjon.2020.29.20.S8 | DOI Listing |
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Evaluation of a national framework for rational use of medicines in Kazakhstan and its role in improving medicine use practices at the organizational and national levels.
BMC Health Serv Res
January 2025
Department of Clinical Pharmacology and Evidence-Based Medicine, NCJSC "Karaganda Medical University", 40, Gogolya St, Karaganda, 100000, Kazakhstan.
Background: Kazakhstan inherited the Semashko health system model, known for the centralized adoption of rules at the Ministry of Health (MoH) level that regulate the healthcare system. In 2019 MoH established a national framework with indicators aimed at collecting qualitative and quantitative data from healthcare organizations as part of their annual self-evaluation, and biannual external evaluation by the National Research Center for Health Development (NRCHD). The purpose of this study was to pilot the MoH framework on rational use of medicines and evaluate its effects on medicine use practices in health care organizations and at the national level.
View Article and Find Full Text PDFPre-processing of paleogenomes: mitigating reference bias and postmortem damage in ancient genome data.
Genome Biol
January 2025
Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
We investigate alternative strategies against reference bias and postmortem damage in low coverage paleogenomes. Compared to alignment to the linear reference genome, we show that masking known polymorphic sites and graph alignment effectively remove reference bias, but only starting from raw read files. We next study approaches to overcome postmortem damage: trimming, rescaling, and our newly developed algorithm, bamRefine (github.
View Article and Find Full Text PDFA Self-Supporting Flexible Electrode for Tracking and Reversible Quantification of Mg2+ and Ca2+ in the Brains of Freely Behaving Animal.
Angew Chem Int Ed Engl
January 2025
East China Normal University, Dept. of Chemistry, Dongchuan Road 500, 200062, Shanghai, CHINA.
Monitoring dynamic neurochemical signals in the brain of free-moving animals remains great challenging in biocompatibility and direct implantation capability of current electrodes. Here we created a self-supporting polymer-based flexible microelectrode (rGPF) with sufficient bending stiffness for direct brain implantation without extra devices, but demonstrating low Young's modulus with remarkable biocompatibility and minimal position shifts. Meanwhile, screening by density functional theory (DFT) calculation, we designed and synthesized specific ligands targeting Mg2+ and Ca2+, and constructed Mg-E and Ca-E sensors with high selectivity, good reversibility, and fast response time, successfully monitoring Mg2+ and Ca2+ in vivo up to 90 days.
View Article and Find Full Text PDFRegulation of calcium homeostasis in endoplasmic reticulum-mitochondria crosstalk: implications for skeletal muscle atrophy.
Cell Commun Signal
January 2025
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Road, Lu Zhou, Luzhou, Sichuan, 646000, China.
This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. Calcium is vital for both regulating muscle excitation-contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium from the endoplasmic reticulum (ER) is mediated by receptors such as the ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R), which is crucial for skeletal muscle contraction.
View Article and Find Full Text PDFInvestigating the trustworthiness of research evidence used to inform public health policy: a qualitative interview study on the use of predatory journal citations in policy documents.
Health Res Policy Syst
January 2025
Telfer School of Management, University of Ottawa, 55 Laurier Ave E, Ottawa, ON, K1N 6N5, Canada.
Evidence-based policymaking has increased policymakers' capacity to make scientifically informed health policy decisions. However, reaping the benefits of this approach requires avoiding untrustworthy research - potential sources of which are predatory journals. In this study, we sought to understand how research cited in policy documents is sourced and evaluated, and identify factors that may be contributing to the citation of predatory journals or other less trustworthy evidence.
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