Penisarins A () and B (), sesquiterpene coumarins with an unusual tricyclic sesquiterpene system, were isolated from endophytic sp. KMU18029. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound showed significant cytotoxicities against two human cancer cell lines, HL-60 and SMMC-7721, with IC values of 3.6 ± 0.2 and 3.7 ± 0.2 μM, respectively.
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| http://dx.doi.org/10.1021/acs.jnatprod.0c00393 | DOI Listing |
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