Women with epilepsy are at increased risk of sexual dysfunction. The aim of this cross-sectional study was to investigate the effect of antiepileptic drugs on sexual function and satisfaction in women with epilepsy. In this cross-sectional study, 80 married women with epilepsy who were under treatment with antiepileptic drugs for at least 1 year were evaluated. Sexual function in patients was assessed using the Female Sexual Function Index. The mean age (± standard deviation [SD]) of women was 28.8 (± 5.9) years. The mean (± SD) duration of epilepsy was 8.6 (± 4.1) years. Thirteen women (16.2%) had focal epilepsy and 67 (83.7%) had generalized epilepsy. The mean (± SD) overall sexual performance of patients was 20.5 (± 4.7). Fifteen patients (21.3%) had decreased sexual function and 78.2% had unfavorable sexual performance. Generalized epilepsy, multi-drug regimen, disease duration of more than 10 years, and age > 30 years were associated with sexual dysfunction. Due to the high prevalence of sexual dysfunction in women with epilepsy, special attention should be given to appropriate management of these patients.
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http://dx.doi.org/10.1007/s12031-020-01744-z | DOI Listing |
Pediatr Infect Dis J
December 2024
From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Introduction: Central nervous system (CNS) infections represent some of the most critical pediatric health challenges, characterized by high mortality rates and a notable risk of long-term complications. Despite their significance, standardized guidelines for endocrinological follow-up of CNS infection survivors are lacking, leading to reliance on the expertise of individual centers and clinicians.
Materials And Methods: Prospective monocentric observational study conducted at the Fondazione Policlinico Universitario Agostino Gemelli in Rome, Italy.
Anesthesiology
January 2025
Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, Boston MA, USA.
Introduction: Accurate prognostication in comatose survivors of cardiac arrest is a challenging and high-stakes endeavor. We sought to determine whether internal EEG subparameters extracted by the Bispectral Index (BIS) monitor, a device commonly used to estimate depth-of-anesthesia intraoperatively, could be repurposed to predict recovery of consciousness after cardiac arrest.
Methods: In this retrospective cohort study, we trained a 3-layer neural network to predict recovery of consciousness to the point of command following versus not based on 48 hours of continuous EEG recordings in 315 comatose patients admitted to a single US academic medical center after cardiac arrest (Derivation cohort: N=181; Validation cohort: N=134).
Hum Genet
January 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
The Genetics of Neurodevelopmental Disorders Lab in Padua provided a new intellectual disability (ID) Panel challenge for computational methods to predict patient phenotypes and their causal variants in the context of the Critical Assessment of the Genome Interpretation, 6th edition (CAGI6). Eight research teams submitted a total of 30 models to predict phenotypes based on the sequences of 74 genes (VCF format) in 415 pediatric patients affected by Neurodevelopmental Disorders (NDDs). NDDs are clinically and genetically heterogeneous conditions, with onset in infant age.
View Article and Find Full Text PDFBackground: Increased uptake on Tau positron-emission tomography (PET) is sometimes observed in the absence of amyloid β accumulation. This A-T+ PET profile might represent primary age-related tauopathy (PART), an amyloid β-independent 3R/4R tauopathy observed in aging brains. Although A-T+ individuals have been shown to follow a different cognitive trajectory compared to A-T- and A+T+ individuals, it remains unknown how they differ in terms of plasma biomarkers.
View Article and Find Full Text PDFBackground: Sleep disturbances are common in Alzheimer's disease (AD) and occur at early stages. Hyperexcitability also arises during sleep and can lead to epileptiform activity and seizures that impact memory consolidation. The underlying mechanisms of sleep disturbances and hyperexcitability in AD pathology remain unclear but are likely associated with changes in brain networks and altered functional connectivity (FC).
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