CD8+ T reg cells play an important role in the maintenance of self-tolerance and can inhibit the development of autoimmune disease. In this issue of JEM, Mishra et al. (https://doi.org/10.1084/jem.20200030) reveal that TGF-β signaling and an Eomes-dependent genetic program contribute to CD8 T reg cell differentiation and function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670959 | PMC |
| http://dx.doi.org/10.1084/jem.20201746 | DOI Listing |
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