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Purpose: This cross-sectional study aimed to clarify the relationship between dysphagia and social isolation among community-dwelling older people.

Methods: The study participants were 238 community-dwelling older people (168 women; mean age, 74.0 ± 5.

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Background: Self-neglect is a significant global public health issue, compromising the health, safety, and well-being of older adults. Despite extensive research on the prevalence and risk factors of self-neglect, the underlying psychosocial mechanisms remain underexplored. Social isolation and aging attitudes have been identified as important correlates of self-neglect; however, the precise interplay between these variables, particularly the mediating role of aging attitudes, has yet to be fully examined in the context of rural older adults.

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Background: Stigma significantly impacts individuals with Parkinson's disease (PD) and their caregivers, exacerbating social isolation, psychological distress, and reducing quality of life (QoL). Although considerable research has been conducted on PD's clinical aspects, the social and emotional challenges, like stigma, remain underexplored. Addressing stigma is crucial for enhancing well-being, fostering inclusivity and improving access to care and support.

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Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality.

Nat Hum Behav

January 2025

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and complement systems.

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